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浙江大学学报（农业与生命科学版）
浙江大学学报(农业与生命科学版)  2015, Vol. 41 Issue (2): 125-132    DOI: 10.3785/j.issn.1008-9209.2014.05.261
生物科学与技术     
器官形态发生探索Ⅱ：独特的哺乳动物模型鹿茸
赵海平1，褚文辉1，陈广信2，李春义1*
1.中国农业科学院特产研究所，特种动物分子生物学国家重点实验室，长春 130112；2.广东海洋大学农学院，广东 湛江 524088
Exploration of organ morphogenesisⅡ: Deer antler as unique mammalian model.
Zhao Haiping1, Chu Wenhui1, Chen Guangxin2, Li Chunyi1*
(1. State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; 2. College of Agriculture, Guangdong Ocean University, Zhanjiang 524088, Guangdong, China)
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摘要： 生物电编码器官形态发生在低等动物中已被证实。由于缺乏哺乳动物的形态发生研究模型，二者之间的关系是否同样适用于哺乳动物至今依然未知。鹿茸是一个复杂的哺乳动物附属器官，其形态发生信息存储于形态发生原胚（鹿前额未来生茸区的骨膜）中。该文1）综述了鹿茸的形态发生原胚及鹿茸发生与再生的影响因素，提出了鹿茸是哺乳动物器官形态发生研究的最佳模型的观点；2）分析了鹿茸形态发生信息的存储位点和复制方式、转移路径，并预测了通过生物电追踪形态发生信息来破解哺乳动物器官生物电密码的研究思路。总之，通过鹿茸这一模型的研究必将为人类器官形态发生的探索奠定理论基础。
Abstract: Morphogenesis is a subject to investigate morphological generation and shape maintenance of organisms. Regeneration can recapitulate the process of morphogenesis. Therefore, lower animals such as planaria were usually used to study morphogenesis, as they can regenerate some parts of their bodies. Correlation between bioelectricity and organ morphogenesis has been observed for lower animals such as amphibians. Whether this finding applies to the situation of mammals including humans is unknown due to lack of mammalian models. Deer antler is a unique mammalian organ that can regenerate annually. Deer antler development initiates from AP (antlerogenic periosteum, the periosteum overlying the frontal crest of prepubertal deer) tissue. Subsequent studies showed that the AP controls the morphogenesis of deer antler. 1) Ectopic antlers formed when APs were removed from normal position to anywhere of deer body. 2) Backward morphology of antlers developed when the APs were rotated 180° from original position. 3) Duplication of APs resulted in the growth of normal antlers. 4) Even minced APs can develop organized antlers. Morphogenetic potential of different regions of AP was also assessed. Antler morphogenetic information was mainly held in the anterior and medial halves of AP. The former is responsible for antler brow tine; and the latter is responsible for other branches of antler. All these features, such as full regeneration and a simple tissue-derivative, only exist in antlers comparing to other mammalian organs. Antlers morphogenesis can be studied by simply manipulating AP. Therefore, deer antler is believed to be an ideal model for organ morphogenesis study in mammals. Bioelectricity results on deer antler morphogenesis is a good beginning to understand the mystery of organ morphogenesis in mammals. In this review, the storage, duplication and transferring pathway of morphogenetic information for deer antlers were analyzed, and preliminary idea for cracking the secret codes of morphogenesis of mammalian organs through tracing bioelectricity was outlined. The findings from deer antler model are expected to be applied to artificial control of organ morphogenesis for mammal to serve for human health.
出版日期: 2015-03-20
CLC:  Q 954.48  
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赵海平
褚文辉
陈广信
李春义

引用本文:

赵海平，褚文辉，陈广信，李春义. 器官形态发生探索Ⅱ：独特的哺乳动物模型鹿茸[J]. 浙江大学学报(农业与生命科学版), 2015, 41(2): 125-132.

Zhao Haiping, Chu Wenhui, Chen Guangxin, Li Chunyi. Exploration of organ morphogenesisⅡ: Deer antler as unique mammalian model.. Journal of Zhejiang University (Agriculture and Life Sciences), 2015, 41(2): 125-132.

链接本文:

http://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2014.05.261    或    http://www.zjujournals.com/agr/CN/Y2015/V41/I2/125

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