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| Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss |
| Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan |
| Shanghai Obstetrics/Gynecology Hospital, Fudan University, Shanghai 200011, China; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China; Department of Biostatistics and Epidemiology, Public Health School, Soochow University, Suzhou 215123, China; Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA |
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Abstract Recurrent pregnancy loss (RPL) is a condition with complex etiologies, to which both genetic and environmental factors may contribute. During the last decade, studies indicated that the expression patterns of the prokineticin receptor (PKR1 and PKR2) are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and RPL on a group of 93 RPL cases and 169 healthy controls. Genotyping of the single nucleotide polymorphisms (SNPs) was performed using a Sequenom MassARRAY iPLEX system. The results revealed a significant association between PKR2 rs6053283 polymorphism and RPL (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
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Received: 25 July 2015
Published: 07 March 2016
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Cite this article:
Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan. Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(3): 218-224.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500180 OR http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I3/218
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