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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2014, Vol. 15 Issue (3): 243-255    DOI: 10.1631/jzus.B1300220
Articles     
Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies
Jie Ding, Hui Xu, Xiang Yin, Fu-rong Zhang, Xiao-ping Pan, Yi-an Gu, Jun-zhu Chen, Xiao-gang Guo
Department of Cardiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Xiuzhou District, Gaozhao Street Community Health Service Center, Jiaxing 314031, China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Columbia University Medical Center, New York, NY 10032, USA
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Abstract  The association between the estrogen receptor α gene (ESR1) PvuII polymorphism (c.454-397T>C) and coronary artery disease (CAD) is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the relationship between PvuII polymorphism and CAD. The polymorphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 PvuII polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 PvuII polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility.

Key words： Estrogen receptor α      gene      Polymorphism      Meta-analysis      Coronary artery disease (CAD)     
Received: 20 August 2013      Published: 04 March 2014
CLC:  R541.4  
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Jie Ding
Fu-rong Zhang
Hui Xu
Xiang Yin
Xiao-ping Pan
Yi-an Gu
Jun-zhu Chen
Xiao-gang Guo
Cite this article:

Jie Ding, Hui Xu, Xiang Yin, Fu-rong Zhang, Xiao-ping Pan, Yi-an Gu, Jun-zhu Chen, Xiao-gang Guo. Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(3): 243-255.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1300220     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2014/V15/I3/243

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