Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2008, Vol. 9 Issue (9): 701-706    DOI: 10.1631/jzus.B0820090
Biotechnology     
Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells
Yu-bin JI, Shi-yong GAO
Postdoctoral Research Station of the Institute of Materia Medica, Center for Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; MOE Engineering Research Center of Natural Anticancer Drugs, Harbin University of Commerce, Harbin 150076, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis. Methods: NAT activity in apoptotic HepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of HepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry. Results: NAT activity was lowered in apoptotic HepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in HepG2 cells. Conclusion: NAT can inhibit apoptosis in HepG2 cells.

Key words： Arylamine N-acetyltransferases (NATs)      Apoptosis      HepG2      Camptothecin (CAM)     
Received: 20 March 2008     
CLC:  Q81  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Yu-bin JI
Shi-yong GAO
Cite this article:

Yu-bin JI, Shi-yong GAO. Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2008, 9(9): 701-706.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820090     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2008/V9/I9/701

[1] Ying-shan Zhou, Yuan-xing Gu, Bao-zhu Qi, Yi-kai Zhang, Xiao-liang Li, Wei-huan Fang. Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(4): 316-323.
[2] Run-ting Huang, Qing Huang, Gen-liang Wu, Chun-guang Chen, Zong-jun Li. Evaluation of the antioxidant property and effects in Caenorhabditis elegans of Xiangxi flavor vinegar, a Hunan local traditional vinegar[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(4): 324-333.
[3] Shu-min Liu, Shi-yi Ou, Hui-hua Huang. Green tea polyphenols induce cell death in breast cancer MCF-7 cells through induction of cell cycle arrest and mitochondrial-mediated apoptosis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(2): 89-98.
[4] Bo Wang, Sheng-yun Lin, Ying-ying Shen, Li-qiang Wu, Zhen-zhen Chen, Jing Li, Zhi Chen, Wen-bin Qian, Jian-ping Jiang. Pure total flavonoids from Citrus paradisi Macfadyen act synergistically with arsenic trioxide in inducing apoptosis of Kasumi-1 leukemia cells in vitro[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(7): 580-585.
[5] Chun-qi Gao, Yin-ling Zhao, Hai-chang Li, Wei-guo Sui, Hui-chao Yan, Xiu-qi Wang. Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(6): 549-559.
[6] Jin-ting Yang, Li-hui Tang, Yun-qing Liu, Yin Wang, Lie-ju Wang, Feng-jiang Zhang, Min Yan. Cisplatin combined with hyperthermia kills HepG2 cells in intraoperative blood salvage but preserves the function of erythrocytes[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(5): 395-403.
[7] Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu. Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(5): 344-354.
[8] Hai-sheng Xu, Sun-jian Lyu, Jie-hao Xu, Bin-jie Lu, Jing Zhao, Song Li, Yi-qun Li, Yu-yin Chen. Effect of lipopolysaccharide on the hemocyte apoptosis of Eriocheir sinensis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(12): 971-979.
[9] Jing-yao Pang, Kui-jun Zhao, Jia-bo Wang, Zhi-jie Ma, Xiao-he Xiao. Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(6): 533-539.
[10] Lei Tian, Xiao-qian Dang, Chun-sheng Wang, Pei Yang, Chen Zhang, Kun-zheng Wang. Effects of sodium ferulate on preventing steroid-induced femoral head osteonecrosis in rabbits[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(5): 426-437.
[11] Sailas Benjamin, Silke Flotho, Torsten B?rchers, Friedrich Spener. Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(2): 115-123.
[12] Qin Fu, Chen He, Zheng-rong Mao. Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(1): 8-24.
[13] Tong-liang Bu, Yu-dong Jia, Jin-xing Lin, Yu-ling Mi, Cai-qiao Zhang. Alleviative effect of quercetin on germ cells intoxicated by 3-methyl-4-nitrophenol from diesel exhaust particles[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(4): 318-326.
[14] Shailendra Kapoor. Artesunate and its emerging anti-neoplastic effects: beyond its role in attenuating tumor growth in osteosarcomas[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(12): 1029-1030.
[15] Yao-wen Wang, Ji-hao Ren, Kun Xia, Shu-hui Wang, Tuan-fang Yin, Ding-hua Xie, Li-hua Li. Effect of mitomycin on normal dermal fibroblast and HaCat cell: an in vitro study[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(12): 997-1005.