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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2008, Vol. 9 Issue (8): 591-601    DOI: 10.1631/jzus.B0820042
Biomedicine     
New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai
Rui-wei GUO, Lan HUANG
Department of Cardiovascular, Xinqiao Hospital, University of the Third Military Medical, Chongqing 400037, China
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Abstract  The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and Orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).

Key words： Store-operated Ca2+ entry (SOCE)      Stromal interaction molecule (STIM)      Orai     
Received: 12 February 2008     
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Rui-wei GUO
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Rui-wei GUO, Lan HUANG. New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2008, 9(8): 591-601.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820042     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2008/V9/I8/591

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