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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2015, Vol. 16 Issue (1): 32-43    DOI: 10.1631/jzus.B1400221
Reviews     
Hypoxia-inducible factor 1 and breast cancer metastasis
Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang
CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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Abstract  Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.

Key words： Breast cancer      Hypoxia-inducible factor 1 (HIF-1)      Metastasis     
Received: 11 August 2014      Published: 05 January 2015
CLC:  R737.9  
  Q2  
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Zhao-ji Liu
Gregg L. Semenza
Hua-feng Zhang
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Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang. Hypoxia-inducible factor 1 and breast cancer metastasis. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(1): 32-43.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400221     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I1/32

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