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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2008, Vol. 9 Issue (1): 16-21    DOI: 10.1631/jzus.B071605
Biomedicine     
A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells
Zuo-fu PENG, Lin-xiang LAN, Fang ZHAO, Jing LI, Qiang TAN, Han-wei YIN, Hui-hui ZENG
Department of Chem-Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China; Department of Geriatric Medicine, Peking University First Hospital, Beijing 100034, China; College of Life Sciences, Peking University, Beijing 100075, China
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Abstract  Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich’s ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.

Key words： Thioredoxin reductase (TrxR)      Novel TrxR inhibitor      1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE)      Apoptosis     
Received: 30 November 2007     
CLC:  R73  
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Zuo-fu PENG
Lin-xiang LAN
Fang ZHAO
Jing LI
Qiang TAN
Han-wei YIN
Hui-hui ZENG
Cite this article:

Zuo-fu PENG, Lin-xiang LAN, Fang ZHAO, Jing LI, Qiang TAN, Han-wei YIN, Hui-hui ZENG. A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2008, 9(1): 16-21.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B071605     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2008/V9/I1/16

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