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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2007, Vol. 8 Issue (6): 439-445    DOI: 10.1631/jzus.2007.B0439
Pharmaceutical Sciences     
Investigation on influencing factors of 5-HMF content in Schisandra
XU Qing, LI Ying-hua, LÜ Xiu-yang
Institute of Pharmaceutical Engineering, Zhejiang University, Hangzhou 310027, China; Department of Internal Medicine, Hospital of Zhejiang University, Hangzhou 310027, China
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Abstract  In order to investigate the influencing factors of 5-hydroxymethyl-2-furaldehyde (5-HMF) content in Schisandra, confirm the theory of 5-HMF deriving mainly from Schisandra processing course, and give some suggestions about the Schisandra processing method, the 5-HMF contents in decoctions of Schisandra under different heating temperature, decocting time, soaking time, processing methods and treatment with different solvents before decocting the Schisandra were measured by RP-HPLC method. The results showed that there is great difference of 5-HMF level in decoctions from differently processed Schisandra and unprocessed Schisandra; decocting time of 60 min has some effects on 5-HMF level in decoctions and there is certain quantity 5-HMF in processed Schisandra itself and very little 5-HMF in unprocessed Schisandra. Heating time, heating temperature and treating solvents all have effect on 5-HMF level in decoction of Schisandra. 5-HMF in Schisandra was mainly from processing course. Both long heating time and high heating temperature can increase 5-HMF level in Schisandra. The production of 5-HMF in Schisandra may have some relationships with some polar components, which can dissolve in water, ethanol and acetone, especially in ethanol. To control processing temperature, processing time and treatment with some solvent is very important for controlling 5-HMF level in Schisandra.

Key words： Schisandra process      Heating temperature      Heating time      5-Hydroxymethyl-2-furaldehyde (5-HMF)     
Received: 21 July 2006     
CLC:  R282.71  
  TQ041+.7  
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XU Qing
LI Ying-hua
LÜ Xiu-yang
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XU Qing, LI Ying-hua, LÜ Xiu-yang. Investigation on influencing factors of 5-HMF content in Schisandra. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(6): 439-445.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2007.B0439     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2007/V8/I6/439

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