Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2006, Vol. 7 Issue (8 ): 12-    DOI: 10.1631/jzus.2006.B0665
    
Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea
BRIJESH S., DASWANI P.G., TETALI P., ROJATKAR S.R., ANTIA N.H., BIRDI T.J.
The Foundation for Medical Research, R.G. Thadani Marg, Worli, Mumbai 400018, India; Naoroji Godrej Centre for Plant Research, Lawkin Ltd. Campus, Shindewadi, Shirwal, Satara 412801, India; The National Chemical Laboratory, Homi Bhabha Road, Pune 411008, India; The Foundation for Research in Community Health, Anand Park, Pune 411007, India
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  While data are available on the effect of medicinal plants on intestinal motility and their antibacterial action, there is a paucity of information on their mode of action on various aspects of diarrheal pathogenicity, namely colonization to intestinal epithelial cells and production/action of enterotoxins. Crude decoction of dried leaves of Pongamia pinnata was evaluated for its antimicrobial (antibacterial, antigiardial and antirotaviral) effect; and its effect on production and action of enterotoxins (cholera toxin, CT; Escherichia coli labile toxin, LT; and E. coli stable toxin, ST); and adherence of enteropathogenic E. coli and invasion of enteroinvasive E. coli and Shigella flexneri to epithelial cells. The decoction had no antibacterial, antigiardial and antirotaviral activity, but reduced production of CT and bacterial invasion to epithelial cells. The observed results indicated that the crude decoction of P. pinnata has selective antidiarrheal action with efficacy against cholera and enteroinvasive bacterial strains causing bloody diarrheal episodes.

Key words： Pongamia pinnata      Medicinal plants      Diarrhea      Antidiarrheal agent      Enterotoxin      Colonization     
Received: 09 March 2006     
CLC:  R282.71  
  R574.62  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
BRIJESH S.
DASWANI P.G.
TETALI P.
ROJATKAR S.R.
ANTIA N.H.
BIRDI T.J.
Cite this article:

BRIJESH S., DASWANI P.G., TETALI P., ROJATKAR S.R., ANTIA N.H., BIRDI T.J.. Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2006, 7(8 ): 12-.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2006.B0665     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2006/V7/I8 /12

[1] Abdul Latif Khan, Syed Abdullah Gilani, Muhammad Waqas, Khadija Al-Hosni, Salima Al-Khiziri, Yoon-Ha Kim, Liaqat Ali, Sang-Mo Kang, Sajjad Asaf, Raheem Shahzad, Javid Hussain, In-Jung Lee, Ahmed Al-Harrasi. Endophytes from medicinal plants and their potential for producing indole acetic acid, improving seed germination and mitigating oxidative stress[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(2): 125-137.
[2] Xiao-juan Xu, Liang Liu, Shu-kun Yao. Nerve growth factor and diarrhea-predominant irritable bowel syndrome (IBS-D): a potential therapeutic target?[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(1): 1-9.
[3] Xiao-ning Yan, Richard A. Sikora, Jing-wu Zheng. Potential use of cucumber (Cucumis sativus L.) endophytic fungi as seed treatment agents against root-knot nematode Meloidogyne incognita[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(3): 219-225.
[4] Belemtougri R.G., Constantin B., Cognard C., Raymond G., Sawadogo L.. Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2006, 7(1 ): 10-.