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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2013, Vol. 14 Issue (8): 664-669    DOI: 10.1631/jzus.BQICC701
Perspectives     
Interleukin-17 and acute coronary syndrome
Sheng-an Su, Hong Ma, Li Shen, Mei-xiang Xiang, Jian-an Wang
Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
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Abstract  Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear, we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism.

Key words： Interleukin-17      Acute coronary syndrome      Atherosclerosis      Inflammation     
Received: 18 June 2013      Published: 30 July 2013
CLC:  R541.4  
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Sheng-an Su
Hong Ma
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Mei-xiang Xiang
Jian-an Wang
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Sheng-an Su, Hong Ma, Li Shen, Mei-xiang Xiang, Jian-an Wang. Interleukin-17 and acute coronary syndrome. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(8): 664-669.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.BQICC701     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2013/V14/I8/664

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