Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2014, Vol. 15 Issue (10): 907-914    DOI: 10.1631/jzus.B1400143
Articles     
Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients
Liang Liu, Bei-ni Liu, Shuo Chen, Miao Wang, Yang Liu, Yan-li Zhang, Shu-kun Yao
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China; Graduate School, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China; Beijing University of Chinese Medicine, Beijing 100029, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  The pathophysiology of irritable bowel syndrome (IBS) is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS (D-IBS). Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits (AML) protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls (P<0.001). Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin (P<0.001). We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS.

Key words： Irritable bowel syndrome (IBS)      Visceral hypersensitivity      Somatic hypersensitivity      Autonomic cardiovascular dysfunction      Low-grade inflammation     
Received: 21 May 2014      Published: 08 October 2014
CLC:  R574.4  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Liang Liu
Bei-ni Liu
Shuo Chen
Miao Wang
Yang Liu
Yan-li Zhang
Shu-kun Yao
Cite this article:

Liang Liu, Bei-ni Liu, Shuo Chen, Miao Wang, Yang Liu, Yan-li Zhang, Shu-kun Yao. Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(10): 907-914.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400143     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2014/V15/I10/907

[1] Xiao-juan Xu, Liang Liu, Shu-kun Yao. Nerve growth factor and diarrhea-predominant irritable bowel syndrome (IBS-D): a potential therapeutic target?[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(1): 1-9.
[2] Liang Liu, Qi-fan Xiao, Yan-li Zhang, Shu-kun Yao. A cross-sectional study of irritable bowel syndrome in nurses in China: prevalence and associated psychological and lifestyle factors[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(6): 590-597.
[3] FAN Yu-jing, CHEN Shu-jie, YU Ying-cong, SI Jian-min, LIU Bin. A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2006, 7(12): 8-.