Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2015, Vol. 16 Issue (11): 897-903    DOI: 10.1631/jzus.B1500053
Articles     
Secondary sentinel lymph node tracing technique: a new method for tracing lymph nodes in radical gastrectomy for advanced gastric cancer
Zong-lin Li, Huai-wu Jiang, Min Song, Liang Xu, Dong Xia, Qing Liu
Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, China; Department of Gastrointestinal Surgery, the Second Affiliated Hospital of North Sichuan Medical College, Mianyang 621000, China; Department of Laboratory Medicine, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: To explore the feasibility and clinical value of secondary sentinel lymph node (SSLN) tracing technique in radical gastrectomy for advanced gastric cancer (AGC). Methods: From January 2009 to June 2011, 247 patients who suffered from gastric angle cancer with metastasis in No. 3 group lymph nodes were divided randomly into groups A and B. Methylthioninium chloride was injected into the peripheral tissue of the metastatic No. 3 group lymph nodes of 138 patients in group A before tumor resections. SSLNs were traced and individual lymphadenectomies were carried out based on the biopsy results of the SSLNs. Standard D2 radical gastrectomies were carried out directly on 109 patients in group B. Postoperative follow-up and survival analysis were carried out for patients in both groups. Results: SSLNs were found in 114 (82.6%) patients in group A. Ninety of those patients (78.9%) demonstrated existing metastasis in SSLNs. According to Kaplan-Meier’s method, the postoperative 3-year cumulative survival rates were 63.5% and 47.5%, and the median survival time were 40 and 36 months for the patients of groups A and B, respectively (P<0.05). Conclusions: The SSLN tracing technique is feasible in radical gastrectomy for AGC. It gives surgeons important information about the terminal status of lymph node metastasis and provides some scientific basis for individual lymphadenectomy.

Key words： Secondary sentinel lymph node (SSLN)      Advanced gastric cancer (AGC)      Individual lymphadenectomy      Survival analysis     
Received: 07 March 2015      Published: 04 November 2015
CLC:  R735.2  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Zong-lin Li
Huai-wu Jiang
Min Song
Liang Xu
Dong Xia
Qing Liu
Cite this article:

Zong-lin Li, Huai-wu Jiang, Min Song, Liang Xu, Dong Xia, Qing Liu. Secondary sentinel lymph node tracing technique: a new method for tracing lymph nodes in radical gastrectomy for advanced gastric cancer. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(11): 897-903.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500053     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I11/897

[1] Qiu-ping Xie, Cheng Xiang, Gang Wang, Ke-feng Lei, Yong Wang. MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(5): 361-366.
[2] Yan-yan Shi, Mo Chen, Yue-xia Zhang, Jing Zhang, Shi-gang Ding. Expression of three essential antioxidants of Helicobacter pylori in clinical isolates[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(5): 500-506.
[3] Ya-nan Zhang, Shi-gang Ding, Liu-huan Huang, Jing Zhang, Yan-yan Shi, Li-jun Zhong. Comparative proteome analysis of Helicobacter pylori clinical strains by two-dimensional gel electrophoresis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(10): 820-827.
[4] CHEN Li, TIAN Hua, CHEN Jian, HE Zhi-gang, TAO Si-feng, LOKESH Gurung, PENG Shu-you. Surgical management of gastric stump cancer: a report of 37 cases[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6(1): 38-42.
[5] Zhong-dong Wang, Fan-yong Qu, Yuan-yuan Chen, Zhang-shen Ran, Hai-yan Liu, Hai-dong Zhang. Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(1): 27-36.
[6] LIU Yong, CHEN Li, PENG Shu-you, CHEN Zhou-xun, HOANG-VU C. Role of CD97stalk and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6( 9): 12-.