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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2005, Vol. 6 Issue ( 9): 12-    DOI: 10.1631/jzus.2005.B0913
    
Role of CD97stalk and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients
LIU Yong, CHEN Li, PENG Shu-you, CHEN Zhou-xun, HOANG-VU C
Department of Surgery, Second Affiliated Hospital, School of Medicine, Yangzhou University, Yangzhou 225001, China; Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Department of Surgery, University of Halle-Wittenberg, Halle, Germany
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Abstract  Objectives: To explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of CD97 and its cellular ligand CD55 in gastric carcinomas. Methods: Tumor and corresponding normal mucosal tissue, collected from 39 gastric carcinoma patients, were examined by immunohistochemistry and RT-PCR for the expression of CD97 and CD55. Results: CD97stalk was strongly stained on scattered tumor cells or small tumor cell clusters at the invasion front of gastric carcinomas. The expression of CD97stalk was frequently observed in tumors of stage I and T1 gastric carcinoma patients. The expression of CD97stalk between Stage I and Stage II, III, IV specimens showed significant difference (P<0.05), between T1 and T2, T3, T4 specimens also showed significant difference (P<0.05). Specimens with tumor invasion depth limited in mucosa of T1 specimens showed higher positive CD55 expression than specimens with the same tumor invasion depth in T2, T3, T4 specimens, the expression of CD55 between T1 and T2, T3, T4 specimens was significantly different (P<0.05). There was strong correlation between the distribution patterns of CD97stalk and CD55 on tumor tissues (r=0.73, P<0.05). Signet ring cell carcinomas frequently contained strong CD97stalk and CD55-staining. Conclusions: Our results suggest that CD97stalk is probably involved in the growth, invasion and aggressiveness of gastric carcinomas by binding its cellular ligand CD55. CD97stalk and CD55 could be useful as molecular markers for prognosis and therapy of gastric carcinoma patients.

Key words： CD97stalk      CD55      Gastric carcinoma      Molecular markers     
Received: 21 April 2005     
CLC:  R735.2  
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LIU Yong
CHEN Li
PENG Shu-you
CHEN Zhou-xun
HOANG-VU C
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LIU Yong, CHEN Li, PENG Shu-you, CHEN Zhou-xun, HOANG-VU C. Role of CD97stalk and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6( 9): 12-.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2005.B0913     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2005/V6/I 9/12

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