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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2015, Vol. 16 Issue (3): 198-207    DOI: 10.1631/jzus.B1400237
Articles     
Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials
Xian-qing Hu, Jian Cheng, Biao Tang, Zhong-heng Zhang, Ke Huang, Yi-ping Yang, Yan-yan Mao, Ming Zhong, Shen-wen Fu
Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, China; Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, China
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Abstract  Objective: To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods: Randomized controlled trials were identified by searching relevant databases published up to April 2nd, 2014. A meta-analysis of eligible studies was performed by Stata 12.0 and Review Manager 5.2 with a fixed-effect model. Results: Ten studies providing adverse cardiac events in a total of 1346 STEMI patients treated with primary PCI were identified. The occurrence of heart failure was significantly reduced in patients treated with postconditioning compared with usual care (risk ratio (RR) 0.533; 95% confidence intervals (CI) 0.368–0.770), whereas non-fatal reinfarction slightly increased in the postconditioning group (RR 2.746; 95% CI 1.007–7.488). No significant difference in total major adverse cardiac events (MACEs) was observed between the two groups (RR 0.876; 95% CI 0.671–1.144). Conclusions: Postconditioning in STEMI patients undergoing primary PCI significantly reduces the risk of heart failure, but fails to decrease the incidence of total MACEs and the risk of non-fatal reinfarction.

Key words： Myocardial infarction      Postconditioning      Coronary intervention     
Received: 31 August 2014      Published: 05 March 2015
CLC:  R542.2  
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Xian-qing Hu
Shen-wen Fu
Jian Cheng
Biao Tang
Zhong-heng Zhang
Ke Huang
Yi-ping Yang
Yan-yan Mao
Ming Zhong
Cite this article:

Xian-qing Hu, Jian Cheng, Biao Tang, Zhong-heng Zhang, Ke Huang, Yi-ping Yang, Yan-yan Mao, Ming Zhong, Shen-wen Fu. Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(3): 198-207.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400237     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I3/198

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