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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2010, Vol. 11 Issue (4): 227-237    DOI: 10.1631/jzus.B0900327
Biomedicine     
Urinary proteomics as a novel tool for biomarker discovery in kidney diseases
Jing Wu, Yi-ding Chen, Wei Gu
Department of Endocrinology and Metabolism, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China, Department of Oncology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
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Abstract  Urine has become one of the most attractive biofluids in clinical proteomics, for its procurement is easy and noninvasive and it contains sufficient proteins and peptides. Urinary proteomics has thus rapidly developed and has been extensively applied to biomarker discovery in clinical diseases, especially kidney diseases. In this review, we discuss two important aspects of urinary proteomics in detail, namely, sample preparation and proteomic technologies. In addition, data mining in urinary proteomics is also briefly introduced. At last, we present several successful examples on the application of urinary proteomics for biomarker discovery in kidney diseases, including diabetic nephropathy, IgA nephropathy, lupus nephritis, renal Fanconi syndrome, acute kidney injury, and renal allograft rejection.

Key words： Clinical proteomics      Urinary proteomics      Biomarker      Kidney diseases     
Received: 20 October 2009      Published: 29 March 2010
CLC:  R57  
  R58  
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Jing Wu
Yi-ding Chen
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Jing Wu, Yi-ding Chen, Wei Gu. Urinary proteomics as a novel tool for biomarker discovery in kidney diseases. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2010, 11(4): 227-237.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0900327     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2010/V11/I4/227

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