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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2007, Vol. 8 Issue (4): 217-220    DOI: 10.1631/jzus.2007.B0217
Biomedicine     
Vascular architecture: is it a helpful histopathological biomarker for hepatocellular carcinoma?
GRIZZI Fabio, FRANCESCHINI Barbara, FIAMENGO Barbara, RUSSO Carlo, DIOGUARDI Nicola
Laboratories of Quantitative Medicine, Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy; Department of Pathology, Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
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Abstract  Hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions. Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue, and discuss why this parameter might provide additional information regarding cancer behavior. The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation, and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.

Key words： Liver      Angiogenesis      Cancer      Fractals      Geometry      Biomarkers     
Received: 13 October 2006     
CLC:  R735.7  
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GRIZZI Fabio
FRANCESCHINI Barbara
FIAMENGO Barbara
RUSSO Carlo
DIOGUARDI Nicola
Cite this article:

GRIZZI Fabio, FRANCESCHINI Barbara, FIAMENGO Barbara, RUSSO Carlo, DIOGUARDI Nicola. Vascular architecture: is it a helpful histopathological biomarker for hepatocellular carcinoma?. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(4): 217-220.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2007.B0217     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2007/V8/I4/217

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