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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2014, Vol. 15 Issue (6): 566-574    DOI: 10.1631/jzus.B1300115
Articles     
Proteins induced by telomere dysfunction are associated with human IgA nephropathy
Ying-ying Lu, Xian Yang, Wen-qing Chen, Zhen-yu Ju, Zhang-fei Shou, Juan Jin, Xiao-hui Zhang, Jiang-hua Chen, Hong Jiang
Kidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Institute of Aging Research and Max-Planck-Research Group on Stem Cell Aging, Hangzhou Normal University, Hangzhou 311121, China
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Abstract  Aging is one of the contributing risk factors for kidney diseases. Accumulating evidence prompts the view that telomere length in kidney tissue cells is an indicator for organismal aging. Previously identified aging markers (cathelin-related antimicrobial peptide (CRAMP), stathmin, elongation factor-1伪 (EF-1伪), and chitinase) were associated not only with telomere driven aging in mice but also with human aging and chronic diseases. This study focuses on the relationship between these biomarkers and IgA nephropathy (IgAN) progression in the Chinese population. For 260 individuals, the four markers are determined in blind datasets using direct enzyme-linked immunosorbent assay (ELISA) and immunofluorescence staining. The expression levels of CRAMP and chitinase increased in blood plasma, urine, and kidney tissues during human IgAN progression. And for the other nephropathy, such as systemic lupus erythematosus (SLE), diabetic nephropathy (DN), and focal segmental glomerulosclerosis (FSGS), there is no protein upregulation with telomere shortening. Moreover, a combination of CRAMP and chitinase can distinguish patients with IgAN from healthy individuals with 88.2%/92.5% (plasma) and 74.3%/84.2% (urine) sensitivity/specificity. These data provide the experimental evidence that telomere shortening and related inflammatory proteins are associated with human IgAN, and it could be a new direction for the disease progression study.

Key words： Biomarkers      Telomere      Table S1')" href="#">IgA nephropathy (IgAN)

The online version of this article contains supplementary Table S1      Table S2')" href="#">Table S2      Fig.S1')" href="#">Fig.S1      Fig.S2

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Received: 16 April 2013      Published: 07 June 2014
CLC:  R58  
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Hong Jiang
Ying-ying Lu
Zhen-yu Ju
Xian Yang
Wen-qing Chen
Zhang-fei Shou
Juan Jin
Xiao-hui Zhang
Jiang-hua Chen
Cite this article:

Ying-ying Lu, Xian Yang, Wen-qing Chen, Zhen-yu Ju, Zhang-fei Shou, Juan Jin, Xiao-hui Zhang, Jiang-hua Chen, Hong Jiang. Proteins induced by telomere dysfunction are associated with human IgA nephropathy. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(6): 566-574.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1300115     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2014/V15/I6/566

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