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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2008, Vol. 9 Issue (2): 90-92    DOI: 10.1631/jzus.B0710621
Medical Genetics     
Mitochondrion and its related disorders: Making a comeback
Xian-ning ZHANG, Ming QI
Zhejiang University-Adinovo Center for Genetic and Genomic Medicine, Zhejiang University, Hangzhou 310058, China; James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310058, China; National Education Base for Basic Medical Sciences, Zhejiang University, Hangzhou 310058, China
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Abstract  The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.

Key words： Mitochondria      Mitochondrial disorder      Mutation     
Received: 04 December 2007      Published: 06 January 2008
CLC:  R394  
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Xian-ning ZHANG, Ming QI. Mitochondrion and its related disorders: Making a comeback. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2008, 9(2): 90-92.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0710621     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2008/V9/I2/90

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