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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2005, Vol. 6 Issue (10): 999-1004    DOI: 10.1631/jzus.2005.B0999
Biotechnology & Biomedicine     
Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulus L.)
HE Guo-qing, XIONG Hao-ping, CHEN Qi-he, RUAN Hui, WANG Zhao-yue, TRAORÉ Lonseny
Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China; Department of Food Science and Nutrition, University of Conakry PB 1147, Guinea
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Abstract  Waste hops are good sources of flavonoids. Extraction of flavonoids from waste hops (SC-CO2 extracted hops) using supercritical fluids technology was investigated. Various temperatures, pressures and concentrations of ethanol (modifier) and the ratio (w/w) of solvent to material were tested in this study. The results of single factor and orthogonal experiments showed that at 50 °C, 25 MPa, the ratio of solvent to material (50%), ethanol concentration (80%) resulted in maximum extraction yield flavonoids (7.8 mg/g). HPLC-MS analysis of the extracts indicated that flavonoids obtained were xanthohumol, the principal prenylflavonoid in hops.

Key words： Optimization      Supercritical fluid extraction      Flavonoids      Xanthohumol      Hops (Humulus lupulus L.)     
Received: 01 March 2005     
CLC:  TS201  
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HE Guo-qing
XIONG Hao-ping
CHEN Qi-he
RUAN Hui
WANG Zhao-yue
TRAORÉ Lonseny
Cite this article:

HE Guo-qing, XIONG Hao-ping, CHEN Qi-he, RUAN Hui, WANG Zhao-yue, TRAORÉ Lonseny. Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulus L.). Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6(10): 999-1004.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2005.B0999     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2005/V6/I10/999

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