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ZJUS-A
Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2002, Vol. 3 Issue (5): 627-631    DOI: 10.1631/jzus.2002.0627
Biotechnology & Life Sciences     
Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection
WU Qin-dong, ZHU Yong-liang, SHI Yi-hai
Department of Gastroenterology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China; Department of Gastroenterology, The First Hospital of Daqing, Daqing 163001, China
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Abstract  Objective: To evaluate the interaction between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and Helicobacter pylori (H. pylori) infection in patients with chronic gastritis and peptic ulcer. Methods: The serum levels of sICAM-1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H. pylori was determined by histologic examination, RUT, 14C - UBT, and serology. The sera obtained from 18 healthy volunteers served as controls. Results: The serum levels of sICAM-1 were significantly higher in patients with H. pylori positive than those of H. pylori negative (889.43±32.52 ng/ml vs. 747.07±30.45 ng/ml, P<0.05). The serum levels of sICAM-1 in patients with mild, moderate and severe infection of H. pylori were 841.68±72.36 ng/ml, 905.43±37.59 ng/ml and 1012.54±49.34 ng/ml, respectively (P<0.05). The serum levels of sICAM-1 proved to be significantly correlated with the density of H. pylori colonization in gastric mucosa (rs=0.316, P<0.001). The serum levels of sICAM-1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls (P<0.05). Conclusions: These results indicated that H. pylori infection up-regulates the expression of sICAM-1.

Key words： Helicobacter pylori      sICAM-1      Serum      Enzyme-linked immunosorbent assay (ELISA)     
Received: 08 January 2002     
CLC:  R573.3  
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WU Qin-dong
ZHU Yong-liang
SHI Yi-hai
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WU Qin-dong, ZHU Yong-liang, SHI Yi-hai. Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2002, 3(5): 627-631.

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http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2002.0627     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2002/V3/I5/627

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