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ZJUS-A
Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2007, Vol. 8 Issue (9): 1521-1526    DOI: 10.1631/jzus.2007.A1521
Materials Science & Chemical Engineering     
Lovastatin production by Aspergillus terreus in solid-state fermentation
WEI Pei-lian, XU Zhi-nan, CEN Pei-lin
Institute of Biochemical Engineering, Department of Chemical Engineering & Bioengineering, Zhejiang University, Hangzhou 310027, China; Department of Biochemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China
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Abstract  Lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation (SSF) was studied. Various substrates were used to evaluate the ability of A. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production in SSF. The maximum yield of lovastatin (2.9 mg/g dry substrate) using rice as substrate was achieved after incubating for 11 d at the following optimized process parameters: 50%~60% initial moisture content, pH 5.5, incubation temperature 28 °C.

Key words： Solid-state fermentation (SSF)      Rice      Lovastatin      Aspergillus terreus     
Received: 08 March 2006     
CLC:  Q93  
  R93  
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WEI Pei-lian
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CEN Pei-lin
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WEI Pei-lian, XU Zhi-nan, CEN Pei-lin. Lovastatin production by Aspergillus terreus in solid-state fermentation. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2007, 8(9): 1521-1526.

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http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2007.A1521     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2007/V8/I9/1521

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