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浙江大学学报（农业与生命科学版）
浙江大学学报(农业与生命科学版)  2014, Vol. 40 Issue (4): 370-378    DOI: 10.3785/j.issn.1008-9209.2014.04.211
综述     
植物非编码小RNA研究进展（英文）
沈恩惠， 刘扬， 叶楚玉， 樊龙江*
（浙江大学农业与生物技术学院农学系/浙江省作物种质资源重点实验室，杭州 310058）
Recent studies on non-coding small RNAs in plants
Shen Enhui, Liu Yang, Ye Chuyu, Fan Longjiang*
(Zhejiang Key Laboratory of Crop Germplasm/Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China)
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摘要： 在植物和动物中存在着大量非编码小RNA，它们通过对靶标mRNA直接切割或在转录后抑制其翻译对基因表达起调控作用.本文主要综述了该领域在以下2方面的研究进展.1）微RNA（miRNA）介导的具有相位排列的小干扰RNA（phasiRNA）：由miRNA介导的phasiRNA可由编码和非编码位点产生；介绍了phasiRNA产生的模式特征，以及phasiRNA和miRNA的进化机制.2）介绍了最近出现的内源miRNA诱捕靶标(endogenous target mimics，eTMs)研究进展，包括利用人工诱捕靶标检验miRNA的功能，通过生物信息学方法在全基因组水平计算识别eTMs等.
Abstract: There are many non-coding small RNAs in plants and animals, which regulate gene expression via direct cleavage of target mRNAs or via inhibition of translation at the posttranscriptional level. In this paper, recent studies on microRNA (miRNA)mediated phased siRNAs (phasiRNA) and endogenous target mimics (eTMs) were reviewed: 1) phasiRNAs can be generated both in coding and noncoding loci, and some require miRNA-mediated cleavage for their biogenesis. Pattern and evolutionary mechanisms of miRNA-mediated phasiRNAs were discussed. 2) Genomewide identification and application of eTMs as miRNA decoy targets were recommended, including the use of artificial target mimics to validate the functions of miRNAs and employing bioinformatics methods to identify eTMs in the wholegenome level.
出版日期: 2014-07-20
CLC:  Q 943  
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沈恩惠
刘扬
叶楚玉
樊龙江

引用本文:

沈恩惠， 刘扬， 叶楚玉， 樊龙江. 植物非编码小RNA研究进展（英文）[J]. 浙江大学学报(农业与生命科学版), 2014, 40(4): 370-378.

Shen Enhui, Liu Yang, Ye Chuyu, Fan Longjiang. Recent studies on non-coding small RNAs in plants. Journal of Zhejiang University (Agriculture and Life Sciences), 2014, 40(4): 370-378.

链接本文:

http://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2014.04.211    或    http://www.zjujournals.com/agr/CN/Y2014/V40/I4/370

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