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浙江大学学报（农业与生命科学版）
浙江大学学报(农业与生命科学版)  2012, Vol. 38 Issue (1): 63-70    DOI: 10.3785/j.issn.1008-9209.2012.01.009
农业科学     
手性农药毒性评价进展
刘维屏,张颖
浙江大学环境与资源学院环境科学研究所,浙江杭州３１００５８
Progress in potential toxicity of chiral pesticides
LIU Wei ping,ZHANG Ying
Institute o f Env ironmental Science , College o f Env ironmental and Resource Sciences , Zhe jiang University , H angz hou 310058 , China
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摘要： 长期以来,手性农药都被当作单一化合物进行环境行为和生态毒性研究,但是由于手性农药对映体与生物大分子相互作用的立体选择性,手性农药对动物及人类的毒性作用可能具有对映体选择性.本文介绍了有机磷、有机氯、拟除虫菊酯、苯基吡唑等手性农药对内分泌、神经、免疫、生殖、发育等毒性作用的对映体选择性,分析了对映体选择性产生的机制,在此基础上提出了未来的研究方向.
Abstract: 　In the past , chiral pesticides were explored as racemic mixtures in environmental fate and ecotoxicities . However , as a result of the enantioselective interactions with chiral molecules , the enantiomers of chiral pesticides may have different potential toxicities to humans and animals . The present review introduced recent findings on enantioselective endocrine disruption , neurotoxicity ,immunotoxicity , reproductive and developmental toxicity of organophosphorus , organochlorines ,pyrethroids and phenylpyrazole pesticides , as well as the underlying mechanisms . Furthermore , the developmental trends of future investigations were discussed .
出版日期: 2012-01-20
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引用本文:

刘维屏,张颖. 手性农药毒性评价进展[J]. 浙江大学学报(农业与生命科学版), 2012, 38(1): 63-70.

LIU Wei ping,ZHANG Ying. Progress in potential toxicity of chiral pesticides. , 2012, 38(1): 63-70.

链接本文:

http://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2012.01.009    或    http://www.zjujournals.com/agr/CN/Y2012/V38/I1/63

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