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工程设计学报
工程设计学报  2025, Vol. 32 Issue (2): 232-239    DOI: 10.3785/j.issn.1006-754X.2025.04.155
优化设计     
基于压电喷墨打印技术的食管支架载药层制备
郑跃靖1,2(),梁文峰1,王婷婷3,李松2,4,朱慧轩2,4,张凯3()
1.沈阳建筑大学 机械工程学院，辽宁 沈阳 110186
2.中国科学院沈阳自动化研究所 机器人学国家重点实验室，辽宁 沈阳 110016
3.中国医科大学附属盛京医院 消化内科内镜诊治中心，辽宁 沈阳 110004
4.中国科学院大学，北京 100049
Preparation of drug-carrying layer of esophageal stent based on piezoelectric inkjet printing technology
Yuejing ZHENG1,2(),Wenfeng LIANG1,Tingting WANG3,Song LI2,4,Huixuan ZHU2,4,Kai ZHANG3()
1.School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110186, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
3.Endoscopy Center of Gastroenterology Department, Shengjing Hospital of China Medical University, Shenyang 110004, China
4.University of Chinese Academy of Sciences, Beijing 100049, China
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摘要：

食管狭窄是食管癌的主要症状之一，目前载药食管支架被广泛应用于食管狭窄的临床治疗。现阶段，载药食管支架的制备方法主要为浸涂法与喷涂法，但该类方法所制备的食管支架载药层的材料受限且覆膜精度不高。为解决上述问题，提出了一种基于压电喷墨打印技术的食管支架载药层制备方法。首先，运用有限元仿真法设计了压电喷墨打印平台的温控箱并优化了温控参数，以促进打印材料固化成形，拓宽载药层的使用材料。然后，深入探究了压电喷头驱动波形的电压幅值、斜率参数及脉冲宽度对液滴直径的影响，并优化了驱动波形参数，以提高载药层的覆膜精度。最后，开展载药层打印实验，以验证温控箱仿真设计与驱动波形参数优化的准确性与有效性。实验结果表明，GelMA（gelatin methacryloyl，甲基丙烯酰化明胶）水凝胶在-4~4 ℃时的成形效果良好；液滴直径与驱动波形的电压幅值和斜率参数均呈正相关，但存在最佳脉冲宽度。在确保打印精度的前提下，确定了上升沿电压幅值为30 V，上升沿斜率和下降沿斜率均为7 V/ms，脉冲宽度为1.5 ms，并利用该驱动波形成功打印了固化成形效果良好、精度高且均匀的食管支架载药层，这可为载药食管支架的制备提供新思路。
关键词： 食管支架;  喷墨打印;  驱动波形;  液滴直径;  GelMA水凝胶    
Abstract:

Esophageal stenosis is one of the main symptoms of esophageal cancer. Currently, the drug-carrying esophageal stents are widely used in the clinical treatment of esophageal stenosis. At present, the main preparation methods of drug-carrying esophageal stents are dip coating method and spray coating method, but the materials of the drug-carrying layer of esophageal stent prepared by these methods were limited and the coating accuracy is not high. To solve the above problems, a method for preparing the drug-carrying layer of esophageal stent based on piezoelectric inkjet printing technology is proposed. Firstly, the finite element simulation method was used to design the temperature control box for the piezoelectric inkjet printing platform and optimize the temperature control parameters, so as to promote the solidification of printing materials and broaden the materials used in the drug-carrying layer. Then, the influence of voltage amplitude, slope parameter and pulse width of the driving waveform for piezoelectric inkjet heads on the droplet diameter was deeply explored, and the driving waveform parameters were optimized to improve the coating accuracy of drug-carrying layer. Finally, the printing experiment for drug-carrying layer was conducted to verify the accuracy and effectiveness of the simulation design of temperature control box and the optimization of driving waveform parameters. The results showed that the GelMA (gelatin methacryloyl) hydrogel had a good forming effect at -4 to 4 ℃. The droplet diameter was positively correlated with the voltage amplitude and slope parameters of the driving waveform, but there was an optimal pulse width. Under the premise of ensuring printing accuracy, the rising edge voltage amplitude was determined to be 30 V, the rising edge slope and the falling edge slope were both 7 V/ms, and the pulse width was 1.5 ms. Using this driving waveform, a uniform drug-carrying layer of esophageal stent with good curing and forming effect and high accuracy was successfully printed, which could provide a new idea for the preparation of drug-carrying esophageal stents.
Key words: esophageal stent    inkjet printing    driving waveform    droplet diameter    GelMA hydrogel
收稿日期: 2024-07-05 出版日期: 2025-05-06
CLC:  TP 391.7  
基金资助: 国家自然科学基金资助项目(52205319);中国科学院青年创新促进会项目(2021200);辽宁省教育厅基本科研项目(JYTQN2023025);沈阳市中青年科技创新人才支持计划项目(RC220482);盛京345人才支持计划资助项目(M1317)
通讯作者: 张凯     E-mail: 1078594170@qq.com;zhangkaidoctor@163.com
作者简介: 郑跃靖（1999—），男，硕士生，从事生物制造研究，E-mail: 1078594170@qq.com
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引用本文:

郑跃靖,梁文峰,王婷婷,李松,朱慧轩,张凯. 基于压电喷墨打印技术的食管支架载药层制备[J]. 工程设计学报, 2025, 32(2): 232-239.

Yuejing ZHENG,Wenfeng LIANG,Tingting WANG,Song LI,Huixuan ZHU,Kai ZHANG. Preparation of drug-carrying layer of esophageal stent based on piezoelectric inkjet printing technology[J]. Chinese Journal of Engineering Design, 2025, 32(2): 232-239.

链接本文:

https://www.zjujournals.com/gcsjxb/CN/10.3785/j.issn.1006-754X.2025.04.155    或    https://www.zjujournals.com/gcsjxb/CN/Y2025/V32/I2/232

图1  压电喷墨打印平台结构示意
图2  压电喷头的驱动波形与工作原理
图3  温控箱仿真模型网格划分
图4  不同温控上盖温度下温控箱及转轴的温度变化规律
图5  驱动波形电压幅值对液滴直径的影响
图6  驱动波形斜率参数对液滴直径的影响
图7  驱动波形脉冲宽度对液滴直径的影响
图8  食管支架载药层打印结果
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