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| Research progress of zebrafish heart regeneration models |
Weijia ZHANG( ),Jinxiu LIANG,Peidong HAN() |
| Institute of Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, China |
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Abstract Heart disease is a major threat to human health due to the high morbidity and mortality rates. As a result, the discovery of adult zebrafish heart regeneration provides a new perspective for the study and treatment of human heart diseases. This study reviewed the zebrafish heart injury models for heart regeneration, such as apex amputation, cryoinjury, genetic ablation of cardiomyocyte models and so on. In addition, we also explored the essential mechanisms underlying heart regeneration, including the spatiotemporal activation of multiple signaling pathways in different cell types, epigenetic reprogramming, coronary revascularization, activation of key development-related transcription factors, and the disassembly and reassembly of cardiomyocyte sarcomeric structure. Analysis of the mechanism of heart regeneration provides more references basis for therapeutic strategies to overcome heart disease in the future.
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Received: 03 March 2021
Published: 04 March 2022
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Corresponding Authors:
Peidong HAN
E-mail: zhangweijia@zju.edu.cn;hanpd@zju.edu.cn
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斑马鱼心脏再生模型及研究进展
心脏病作为一种发病率和死亡率很高的疾病，严重威胁人类身体健康。斑马鱼作为模式生物，其成体心脏再生功能的发现，为研究和治疗心脏疾病拓展了新的视角。本文综述了多种斑马鱼心脏损伤模型，包括心尖切除损伤、冰冻损伤以及心肌细胞遗传消融模型等；并深入探讨了心脏再生过程中的关键生物学过程，包括多种信号通路在不同细胞类型的时序性激活、心肌细胞表观遗传学编程、冠状血管新生、发育相关关键转录因子的激活以及心肌细胞肌节结构的解离和重构等。对心脏再生机制的解析有望为人类心脏疾病的治疗提供新的思路和干预策略。
关键词：
斑马鱼,
心脏再生,
心脏损伤模型,
心外膜细胞,
心内膜细胞,
成纤维细胞,
免疫细胞
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