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| Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority |
| Yu-xin Guo, Jian-gang Chen, Yan Wang, Jiang-wei Yan, Jing Chen, Tian-hua Yao, Li-ping Zhang, Guang Yang, Hao-tian Meng, Yu-dang Zhang, Ting Mei, Yao-shun Liu, Qian Dong, Bo-feng Zhu |
| Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China; Research Center of Stomatology, Stomatological Hospital, Xi\'an Jiaotong University, Xi'an 710004, China; Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, China; Criminal Police Detachment of Yili Public Security Bureau, Yili 835000, China; Key Laboratory of Genome Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Department of General Dentistry, Stomatological Hospital, Xi\'an Jiaotong University, Xi'an 710004, China; Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, California 92354, USA |
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Abstract The population genetic data and forensic parameters of 19 X-chromosome short tandem repeat (X-STR) loci in Chinese Uygur ethnic minority are presented. These loci were detected in a sample of 233 (94 males and 139 females) unrelated healthy individuals. We observed 238 alleles at the 19 X-STR loci, with the corresponding gene frequencies spanning the range from 0.0021 to 0.5644. After Bonferroni correction (P>0.0026), there were no significant deviations from Hardy-Weinberg equilibrium. The cumulative power of discrimination in females and males, and the probability of exclusion of the 19 X-STR loci were 0.999 999 999 999 999 999 998 091, 0.999 999 999 999 966, and 0.999 999 986 35, respectively. The cumulative mean exclusion chance was 0.999 999 992 849 in deficiency cases, 0.999 999 999 999 628 in normal trios, and 0.999 999 998 722 in duo cases. The high value of the forensic parameters mentioned above revealed that the novel panel of 19 loci had important values for forensic applications in the Uygur group.
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Received: 22 September 2015
Published: 04 May 2016
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Cite this article:
Yu-xin Guo, Jian-gang Chen, Yan Wang, Jiang-wei Yan, Jing Chen, Tian-hua Yao, Li-ping Zhang, Guang Yang, Hao-tian Meng, Yu-dang Zhang, Ting Mei, Yao-shun Liu, Qian Dong, Bo-feng Zhu. Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(5): 367-374.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500228 OR http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I5/367
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