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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2013, Vol. 14 Issue (3): 207-215    DOI: 10.1631/jzus.B1200101
Articles     
Methylenetetrahydrofolate reductase C677T polymorphism predicts response and time to progression to gemcitabine-based chemotherapy for advanced non-small cell lung cancer in a Chinese Han population
Wei Hong, Kai Wang, Yi-ping Zhang, Jun-yan Kou, Dan Hong, Dan Su, Wei-min Mao, Xin-min Yu, Fa-jun Xie, Xiao-jian Wang
Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China; Zhejiang Key Laboratory of the Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou 310022, China; Department of Respiratory Medicine, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Department of Medical Oncology, Hangzhou Cancer Hospital, Hangzhou 310002, China; Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou 310058, China
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Abstract  Objective: The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase (MTHFR) C677T excision repair cross-complementation group 1 (ERCC1) genetic polymorphisms and the clinical efficacy of gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC). Methods: A total of 135 chemonaive patients with unresectable advanced NSCLC were treated with gemcitabine/platinum regimens. The polymorphisms of MTHFR C677T, ERCC1 C8092A, and ERCC1 C118T were genotyped using the TaqMan methods. Results: The overall response rate was 28.9%. Patients with MTHFR CC genotype had a higher rate of objective response than patients with variant genotype (TT or CT) (41.2% versus 19.1%, P=0.01). Median time to progression (TTP) of patients with MTHFR CC genotype was longer than that of patients with variant genotype (7.6 months versus 5.0 months, P=0.003). No significant associations were obtained between ERCC1 C118T and C8092A polymorphisms and both response and survival. Conclusions: Our data suggest the value of MTHFR C677T polymorphism as a possible predictive marker of response and TTP in advanced NSCLC patients treated with gemcitabine/platinum.

Key words： Non-small cell lung cancer      Single nucleotide polymorphism      Methylenetetrahydrofolate reductase      Gemcitabine      Excision repair cross-complementation group 1     
Received: 29 March 2012      Published: 06 March 2013
CLC:  R734.2  
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Wei Hong
Fa-jun Xie
Xiao-jian Wang
Yi-ping Zhang
Kai Wang
Jun-yan Kou
Dan Hong
Dan Su
Wei-min Mao
Xin-min Yu
Cite this article:

Wei Hong, Kai Wang, Yi-ping Zhang, Jun-yan Kou, Dan Hong, Dan Su, Wei-min Mao, Xin-min Yu, Fa-jun Xie, Xiao-jian Wang. Methylenetetrahydrofolate reductase C677T polymorphism predicts response and time to progression to gemcitabine-based chemotherapy for advanced non-small cell lung cancer in a Chinese Han population. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(3): 207-215.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1200101     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2013/V14/I3/207

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