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| Early effects of oral administration of omeprazole and roxatidine on intragastric pH |
| Hiroshi Iida, Shingo Kato, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroki Endo, Kunihiro Hosono, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Masahiko Inamori |
| Gastroenterology Division, Yokohama City University School of Medicine, Yokohama 236-0004, Japan, Department of Medical Education, Yokohama City University School of Medicine, Yokohama 236-0004, Japan, Office of Postgraduate Medical Education, Yokohama City University Hospital, Yokohama 236-0004, Japan |
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Abstract Objective: The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress-related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg. Methods: Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period. Results: During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole (median: 4.45 vs. 2.65; P=0.0367). Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg (median: 90.6% vs. 55.2%, P=0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively). Conclusions: In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.
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Received: 14 March 2011
Published: 30 December 2011
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Cite this article:
Hiroshi Iida, Shingo Kato, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroki Endo, Kunihiro Hosono, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Masahiko Inamori. Early effects of oral administration of omeprazole and roxatidine on intragastric pH. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(1): 29-34.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1100078 OR http://www.zjujournals.com/xueshu/zjus-b/Y2012/V13/I1/29
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