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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2009, Vol. 10 Issue (12): 920-927    DOI: 10.1631/jzus.B0920279
Biomedicine     
Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis
Mei-ying SHAO, Ping HUANG, Ran CHENG, Tao HU
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
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Abstract  Objective: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. Material and methods: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 −174 G/C and −572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 −6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well. Results and conclusion: The present meta-analysis indicates that the IL-6 −174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And −572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.

Key words： Interleukin-6      Polymorphism      Periodontitis      Risk      Meta-analysis     
Received: 08 September 2009     
CLC:  R78  
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Mei-ying SHAO
Ping HUANG
Ran CHENG
Tao HU
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Mei-ying SHAO, Ping HUANG, Ran CHENG, Tao HU. Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2009, 10(12): 920-927.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0920279     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2009/V10/I12/920

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