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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2015, Vol. 16 Issue (9): 796-804    DOI: 10.1631/jzus.B1500005
Articles     
Invasive fungal infection in allogeneic hematopoietic stem cell transplant recipients: single center experiences of 12 years
Ji-min Shi, Xu-ying Pei, Yi Luo, Ya-min Tan, Ru-xiu Tie, Jing-song He, Wei-yan Zheng, Jie Zhang, Zhen Cai, Mao-fang Lin, He Huang
Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
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Abstract  Invasive fungal infection (IFI) is a growing cause of morbidity and mortality among patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively reviewed the records of 408 patients undergoing allo-HSCTs during the period November 1998 to December 2009, analyzed the incidence and risk factors of IFI, and examined the impact of IFI on overall survival. A total of 92 (22.5%) episodes suffered proven or probable IFI (4 patients were proven, 88 patients were probable). Candida was the most common pathogen for early IFI, and mold was the most frequent causative organism for late IFI. A prior history of IFI, human leukocyte antigen (HLA) mismatch, long-time neutropenia, and acute graft-versus-host-disease (GVHD) were risk factors for early IFI. A prior history of IFI, corticosteroid therapy, cytomegalovirus (CMV) disease, and chronic GVHD were risk factors for late IFI. IFI-related mortality was 53.26%. The 12-year overall survival (OS) rate for IFI was significantly lower than that of patients without IFI (41.9% vs. 63.6%, P<0.01).

Key words： Invasive fungal infection      Allogeneic hematopoietic stem cell transplantation      Incidence      Risk factors     
Received: 04 January 2015      Published: 05 September 2015
CLC:  R55  
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Articles by authors
Ji-min Shi
Zhen Cai
Mao-fang Lin
He Huang
Xu-ying Pei
Yi Luo
Ya-min Tan
Ru-xiu Tie
Jing-song He
Wei-yan Zheng
Jie Zhang
Cite this article:

Ji-min Shi, Xu-ying Pei, Yi Luo, Ya-min Tan, Ru-xiu Tie, Jing-song He, Wei-yan Zheng, Jie Zhang, Zhen Cai, Mao-fang Lin, He Huang. Invasive fungal infection in allogeneic hematopoietic stem cell transplant recipients: single center experiences of 12 years. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(9): 796-804.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500005     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I9/796

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