| Biomedicine |
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| Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis |
| Xi-ping ZHANG, Han-qing CHEN, Fang LIU, Jie ZHANG |
| Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, China; The First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China; Department of Acupuncture and Moxibustion, Hangzhou Hospital of Red Cross Society, Hangzhou 310003, China |
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Abstract During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.
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Received: 30 August 2008
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