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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2008, Vol. 9 Issue (7): 567-571    DOI: 10.1631/jzus.B0820048
Biotechnology and Biochemistry     
Attenuating effect of daidzein on polychlorinated biphenyls-induced oxidative toxicity in mouse testicular cells
Da-lei ZHANG, Yu-ling MI, Kai-ming WANG, Wei-dong ZENG, Cai-qiao ZHANG
College of Animal Sciences, Zhejiang University, Hangzhou 310029, China; Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China
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Abstract  The attenuating effect of daidzein (DAI) on oxidative toxicity induced by Aroclor 1254 (A1254) was investigated in mouse testicular cells. Cells were exposed to A1254 alone or with DAI. The oxidative damage was estimated by measuring malondialdehyde (MDA) formation, superoxide dismutase (SOD) activity and glutathione (GSH) content. Results show that A1254 induced a decrease of germ cell number, an elevation in thiobarbituric acid reactive substances (TBARS) but a decrease in SOD activity and GSH content. However, simultaneous supplementation with DAI decreased TBARS level and increased SOD activity and GSH content. Consequently, dietary DAI may restore the intracellular antioxidant system to attenuate the oxidative toxicity of A1254 in testicular cells.

Key words： Daidzein (DAI)      Polychlorinated biphenyl (PCB)      Oxidative damage      Germ cell     
Received: 17 February 2008     
CLC:  Q95  
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Da-lei ZHANG
Yu-ling MI
Kai-ming WANG
Wei-dong ZENG
Cai-qiao ZHANG
Cite this article:

Da-lei ZHANG, Yu-ling MI, Kai-ming WANG, Wei-dong ZENG, Cai-qiao ZHANG. Attenuating effect of daidzein on polychlorinated biphenyls-induced oxidative toxicity in mouse testicular cells. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2008, 9(7): 567-571.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820048     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2008/V9/I7/567

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