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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2012, Vol. 13 Issue (5): 364-371    DOI: 10.1631/jzus.B1100381
Articles     
Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants
Dan-li Fu, Qiao-hong Jiang, Fu-ming He, Guo-li Yang, Li Liu
Department of General Dentistry, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; Department of Oral Implantology, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China) (3Department of Prosthodontics, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
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Abstract  The purpose of this study was to analyze the effect of strontium-substituted hydroxyapatite (Sr-HA) on bone osseointegration of the implants using fluorescence microscopy. We allocated 20 implants to two groups: Sr-HA group and HA group. Electrochemically deposited HA and Sr-HA coatings were applied onto the implants separately. All the implants were inserted into femur bone of rabbits. Oxytetracycline hydrochloride, alizarin-complexon, and calcein green were respectively administered 7, 28, and 46 d after the implantation. After eight weeks, femurs were retrieved and prepared for the fluorescence microscopy observation. We analyzed the bone mineral apposition rates (MARs), bone area ratios (BARs), and bone to implant contact (BIC) of the two groups. Fluorescence microscopic observation showed that all groups exhibited extensive early peri-implant bone formation. The MAR of the Sr-HA group was greater than that for pure HA from 7 to 28 d after implantation, but no significant difference was found at later stage. And the BIC showed difference at 7 and 28 d compared with pure HA. We concluded that Sr-HA coating can improve the bone osseointegration of the implant in the early stage compared with the HA coating.

Key words： Strontium-substituted hydroxyapatite      Hydroxyapatite      Osseointegration     
Received: 21 December 2011      Published: 04 May 2012
CLC:  R782.12  
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Dan-li Fu
Qiao-hong Jiang
Fu-ming He
Guo-li Yang
Li Liu
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Dan-li Fu, Qiao-hong Jiang, Fu-ming He, Guo-li Yang, Li Liu. Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(5): 364-371.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1100381     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2012/V13/I5/364

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