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| Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations |
| Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS |
| Department of Forensic Medicine, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China; Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi'an Jiaotong University, Xi'an 710061, China; Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA; Shaan\'xi Blood Center, Xi'an 710061, China; Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA; Department of Public Health, School of Medicine, Xi\'an Jiaotong University, Xi\'an 710061, China; Center of Forensic Sciences, Beijing Genomics Institute, Beijing 101300, China; Faculty of Basic Medical Science, Nanchang University, Nanchang 330006, China |
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Abstract Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A*2402 (32.46%), A*1101 (26.32%), and A*0203 (10.09%) at the HLA-A locus and B*4601 (12.28%), B*1525 (10.09%), B*4001 (8.77%), and B*3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A*2402-B*1525 (7.86%) and A*0203-B*3802 (5.64%), followed by A*1101-B*4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.
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Received: 01 August 2009
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Cite this article:
Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS. Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2010, 11(2): 127-135.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0900232 OR http://www.zjujournals.com/xueshu/zjus-b/Y2010/V11/I2/127
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