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| HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations |
| Li Shi, Xiao-qin Huang, Lei Shi, Yu-fen Tao, Yu-feng Yao, Liang Yu, Ke-qin Lin, Wen Yi, Hao Sun, Katsushi Tokunaga, Jia-you Chu |
| Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China, Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan |
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Abstract A study of the human leukocyte antigen (HLA) genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, transplantation, and anthropology. In the present study, we report the comprehensive HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in the Zhuang population of southern China for the first time. A total of 13 HLA-A, 24 HLA-B, 22 HLA-C, and 18 HLA-DRB1 were identified in 104 Zhuang individuals. The frequencies of HLA-A*11:01, A*02:07, A*24:02, A*02:03, and A*33:03 on A loci, B*15:02, B*58:01, B*46:01, and B*13:01 on B loci, C*03:04, C*08:01, C*01:02, C*03:02, and C*07:02 on C loci, and DRB1*15:01, DRB1*16:02, DRB1*14:01, DRB1*15:02, and DRB1*03:01 on the DRB1 loci were >10%. The A*33:03-C*03:02-B*58:01-DRB1*03:01 and A*02:07-C*01:02-B*46:01-DRB1*14:01 haplotypes were predominant in the Zhuang. The phylogenetic tree, as well as the analysis of haplotypes, suggested that the Zhuang are genetically similar to southern Chinese populations, especially the Zhuang-Dong language-speaking populations, such as the Bouyei, Dai, and Maonan. Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes, the Zhuang has maintained its unique genetic characteristics.
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Received: 26 July 2010
Published: 07 June 2011
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Cite this article:
Li Shi, Xiao-qin Huang, Lei Shi, Yu-fen Tao, Yu-feng Yao, Liang Yu, Ke-qin Lin, Wen Yi, Hao Sun, Katsushi Tokunaga, Jia-you Chu. HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(6): 428-435.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1000285 OR http://www.zjujournals.com/xueshu/zjus-b/Y2011/V12/I6/428
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