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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2007, Vol. 8 Issue (8): 575-579    DOI: 10.1631/jzus.2007.B0575
Biomedicine     
Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention
ZHOU Bin-quan, TAHK Seung-Jea
Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; Department of Cardiology, School of Medicine, Ajou University, Suwon 443749, Korea
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Abstract  Objective: The beneficial effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has been well established, but there is the problem of no-reflow phenomenon which is an adverse prognostic factor in primary PCI. In the present study the effect of a distal protection device (PercuSurge GuardWire; GW) on epicardial blood flow and myocardial perfusion was evaluated. Methods and Results: Patients with AMI were randomly divided into 2 groups, the GW and the control groups. The GW group included 52 patients with AMI who underwent primary PCI with GW protection and the control group included 60 patients who underwent primary PCI without GW protection. Epicardial blood flow in the infarct-related artery (IRA) and myocardial perfusion were evaluated according to the thrombolysis in myocardial infarction (TIMI) flow grade and the myocardial blush grade (MBG). We found TIMI score of 3 was obtained significantly more frequently in the GW group (96%) than in the control group (80%). The MBG score of 3 was obtained also significantly greater in the GW group (65%) than in the control group (33%). Conclusion: Primary PCI with GW protection can significantly improve epicardial blood flow and myocardial perfusion.

Key words： Acute myocardial infarction (AMI)      Distal protection device      Percutaneous coronary intervention (PCI)     
Received: 08 August 2006     
CLC:  R54  
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ZHOU Bin-quan
TAHK Seung-Jea
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ZHOU Bin-quan, TAHK Seung-Jea. Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(8): 575-579.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2007.B0575     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2007/V8/I8/575

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