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ZJUS-A
Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2004, Vol. 5 Issue (12): 1621-1628    DOI: 10.1631/jzus.2004.1621
Biotechnology     
Enhancing the quality metric of protein microarray image
WANG Li-qiang, NI Xu-xiang, LU Zu-kang, ZHENG Xu-feng, LI Ying-sheng
State Key Lab of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, China
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Abstract  The novel method of improving the quality metric of protein microarray image presented in this paper reduces impulse noise by using an adaptive median filter that employs the switching scheme based on local statistics characters; and achieves the impulse detection by using the difference between the standard deviation of the pixels within the filter window and the current pixel of concern. It also uses a top-hat filter to correct the background variation. In order to decrease time consumption, the top-hat filter core is cross structure. The experimental results showed that, for a protein microarray image contaminated by impulse noise and with slow background variation, the new method can significantly increase the sig-nal-to-noise ratio, correct the trends in the background, and enhance the flatness of the background, the consistency of the signal intensity.

Key words： Protein microarray      Image enhancement      Filter      Noise     
Received: 21 July 2003     
CLC:  TN911.73  
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NI Xu-xiang
WANG Li-qiang
LU Zu-kang
ZHENG Xu-feng
LI Ying-sheng
Cite this article:

WANG Li-qiang, NI Xu-xiang, LU Zu-kang, ZHENG Xu-feng, LI Ying-sheng. Enhancing the quality metric of protein microarray image. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2004, 5(12): 1621-1628.

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http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2004.1621     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2004/V5/I12/1621

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