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ZJUS-A
Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2001, Vol. 2 Issue (3): 275-277    DOI: 10.1631/jzus.2001.0275
Science & Engineering     
A SIMPLE METHOD FOR CHIRAL RESOLUTION OF 1,1\'-BI-2-NAPHTHOL
LI Xiao-tao, JIANG Guang-guang, CHEN Wei-xiang, XU Zhu-de
Department of Chemistry, Zhejiang University, Hangzhou 310027, China
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Abstract  An improved method for preparing enantiomerically pure 1,1\'-bi-2-naphthols is described. 1,1\'-bi-2-naphthol boric anhydride was generated from the reaction of racemic 1,1\'-bi-2-naphthol and boric anhydride. Its two diastereoisomers could be efficiently separated in THF using (L)-proline as the resolving agent. Treatment in three successive steps yielded 79% and 74% enantiomerically pure (S)- and (R)-1,1\'-bi-2-naphthol respectively.

Key words： 1,1\'-bi-2-naphthol      chiral resolution     
Received: 07 October 2000     
CLC:  O621.14+4  
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JIANG Guang-guang
LI Xiao-tao
CHEN Wei-xiang
XU Zhu-de
Cite this article:

LI Xiao-tao, JIANG Guang-guang, CHEN Wei-xiang, XU Zhu-de. A SIMPLE METHOD FOR CHIRAL RESOLUTION OF 1,1\'-BI-2-NAPHTHOL. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2001, 2(3): 275-277.

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http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2001.0275     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2001/V2/I3/275

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