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Vis Inf
Vis Inf  2021, Vol. 5 Issue (1): 1-13    DOI: 10.1016/j.visinf.2020.11.003
论文     
计算机化的细胞跟踪：当前方法，工具和挑战
Neda Emamia,Zahra Sedaeib, Reza Ferdousia
aDepartment of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, 5166/15731, Iran bDepartment of Health Services Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, 5166/15731, Iran
Computerized cell tracking: Current methods, tools and challenges
Neda Emamia,Zahra Sedaeib, Reza Ferdousia
aDepartment of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, 5166/15731, Iran bDepartment of Health Services Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, 5166/15731, Iran
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摘要： 在发育生物学中，对细胞结构及其（形态）动态行为的了解，有助于全面理解它们的行为及其参与机制。这些知识是生物学研究以及所有药物开发，药物或预防性疗法的决定性因素。基于实验的细胞分析不仅困难、昂贵而且耗时。为了克服这些困难，近年来，在细胞科学中已经开发了几种计算化的对象跟踪方法、软件系统和程序包，其中组合了不同学科和技术分支。 对象跟踪是在序列图像中定位和监控特定对象及其行为的过程。本文提供了对细胞跟踪中的对象跟踪阶段和所采用计算方法的全面综述。此外，还回顾了在处理这一领域内延时显微镜图像时可用的软件包和工具包，面对的挑战及其解决方案。描述计算细胞跟踪方法和工具旨在使生物学家和细胞科学家能运用这些可计算技术，构建一种新的方法来获取他们感兴趣问题的进一步信息。

关键词： 细胞跟踪;  数字细胞跟踪;  活细胞显微镜;  图像分析;  生物图像信息学;  亚细胞定位     
Abstract: In developmental biology, knowledge of cell structure and their (morpho) dynamic behavior, leads to a comprehensive understanding of their conducts and the mechanisms in which they participate. This knowledge is a decisive factor in biological research and also in all drug development steps, medicinal or preventive therapies. Experimental cell analysis is hard, expensive, and time-consuming. To overcome these difficulties, in recent years, several computational object tracking methods, software system and packages have been developed in cell sciences that bring together different disciplines and branches of technologies. Object tracking is the process of locating and monitoring specific object and its behavior in sequential images. In this paper, a comprehensive review on object tracking stages and computational methods that are utilized in terms of cell tracking has been organized. Besides, the available software packages and toolkits, challenges, and their solution in time lapse microscopy images in this scope were reviewed. The aim of describing computational cell tracking methods and tools is that biologist and cell scientists might take advantage of these computational techniques to find another method to gain complementary information for their question of interest.
Key words: Cell tracking    Digital cell tracking    Live-cell microscopy    Image analysis    Bioimage informatics    Subcellular location
出版日期: 2021-01-19
通讯作者: Neda Emami     E-mail: neda.emami72@gmail.com
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Neda Emami
Zahra Sedaei
Reza Ferdousi

引用本文:

Neda Emami, Zahra Sedaei, Reza Ferdousi. Computerized cell tracking: Current methods, tools and challenges. Vis Inf, 2021, 5(1): 1-13.

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http://www.zjujournals.com/vi/CN/10.1016/j.visinf.2020.11.003    或    http://www.zjujournals.com/vi/CN/Y2021/V5/I1/1

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