Please wait a minute...
Food Qual Safet
Food Qual Safet
Reviews     
类胡萝卜素代谢调节线粒体功能
Carotenoid metabolism in mitochondrial function
Peiran Lu, Siau Yen Wong, Lei Wu and Dingbo Lin
Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA
 全文: PDF 
摘要： 线粒体是在大多数真核生物中高度活跃的细胞器。现在广泛认为线粒体最初是由原核细菌（如蛋白细菌）进化而来的。线粒体有其独立的基因组，编码37个基因，其中包括13个氧化磷酸化基因。越来越多的证据表明，线粒体不仅能通过提供三磷酸腺苷为细胞提供动力，而且在细胞的命运和功能中起着信号细胞器的作用。许多因素可以影响线粒体的结构和功能。类胡萝卜素是一大类脂溶性色素，常见于我们的饮食中。近年来，类胡萝卜素作为一种膳食生物活性物质，在线粒体结构和功能中对人类健康和疾病的影响引起人们的广泛关注。但其作用机理的研究还很有限。本文我们更新了线粒体作为信号细胞器在人类健康和疾病中的最新进展，总结了类胡萝卜素在线粒体氧化还原稳态、生物合成和自噬的调节中的潜在作用，并讨论了类胡萝卜素调节线粒体功能的可能途径。
关键词： β-胡萝卜素加氧酶2;  炎症;  线粒体DNA释放;  线粒体呼吸超复合物;  线粒体信号转导    
Abstract: Mitochondria are highly dynamic organelles that are found in most eukaryotic organisms. It is broadly accepted that mitochondria originally evolved from prokaryotic bacteria, e.g. proteobacteria. The mitochondrion has its independent genome that encodes 37 genes, including 13 genes for oxidative phosphorylation. Accumulative evidence demonstrates that mitochondria are not only the powerhouse of the cells by supplying adenosine triphosphate, but also exert roles as signalling organelles in the cell fate and function. Numerous factors can affect mitochondria structurally and functionally. Carotenoids are a large group of fat-soluble pigments commonly found in our diets. Recently, much attention has been paid in carotenoids as dietary bioactives in mitochondrial structure and function in human health and disease, though the mechanistic research is limited. Here, we update the recent progress in mitochondrial functioning as signalling organelles in human health and disease, summarize the potential roles of carotenoids in regulation of mitochondrial redox homeostasis, biogenesis, and mitophagy, and discuss the possible approaches for future research in carotenoid regulation of mitochondrial function.
Key words: β-carotene oxygenase 2    inflammation    mitochondrial DNA release    mitochondrial respiratory supercomplex    mitochondrial signalling
通讯作者: Dingbo Lin     E-mail: dingbo.lin@okstate.edu
服务　　
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章　　
Peiran Lu
Siau Yen Wong
Lei Wu
Dingbo Lin

引用本文:

Peiran Lu, Siau Yen Wong, Lei Wu, Dingbo Lin. Carotenoid metabolism in mitochondrial function. Food Qual Safet, 10.1093/fqsafe/fyaa023.

链接本文:

http://www.zjujournals.com/fqs/CN/10.1093/fqsafe/fyaa023    或    http://www.zjujournals.com/fqs/CN/Y2020/V4/I3/115

No related articles found!