| Articles |
|
|
|
|
| Propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing |
| Pawe? Olczyk, Katarzyna Komosińska-Vassev, Katarzyna Winsz-Szczotka, Ewa M. Ko?ma, Grzegorz Wisowski, Jerzy Stojko, Katarzyna Klimek, Krystyna Olczyk |
| Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, 41-200 Sosnowiec, Poland; Center of Experimental Medicine, Medical University of Silesia, 40-752 Katowice, Poland; Department of Statistics, Medical University of Silesia, 41-200 Sosnowiec, Poland |
|
|
|
Abstract Objective: This study was aimed at assessing the dynamics of vitronectin (VN), laminin (LN), and heparan sulfate/heparin (HS/HP) content changes during experimental burn healing. Methods: VN, LN, and HS/HP were isolated and purified from normal and injured skin of domestic pigs, on the 3rd, 5th, 10th, 15th, and 21st days following thermal damage. The wounds were treated with apitherapeutic agent (propolis), silver sulfadiazine (SSD), physiological salt solution, and propolis vehicle. VN and LN were quantified using an immunoenzymatic assay and HS/HP was estimated by densitometric analysis. Results: Propolis treatment stimulated significant increases in VN, LN, and HS/HP contents during the initial phase of study, followed by a reduction in the estimated extracellular matrix molecules. Similar patterns, although less extreme, were observed after treatment with SSD. Conclusions: The beneficial effects of propolis on experimental wounds make it a potential apitherapeutic agent in topical burn management.
|
|
Received: 03 October 2011
Published: 05 November 2012
|
|
|
|
Cite this article:
Pawe? Olczyk, Katarzyna Komosińska-Vassev, Katarzyna Winsz-Szczotka, Ewa M. Ko?ma, Grzegorz Wisowski, Jerzy Stojko, Katarzyna Klimek, Krystyna Olczyk. Propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(11): 932-941.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1100310 OR http://www.zjujournals.com/xueshu/zjus-b/Y2012/V13/I11/932
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
