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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2011, Vol. 12 Issue (10): 828-834    DOI: 10.1631/jzus.B1100165
    
Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma
Kai Wang, Min Zhang, Ying-ying Qian, Zhe-yuan Ding, Jun-hui Lv, Hua-hao Shen
Department of Respiratory Medicine, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China, School of Medicine, Zhejiang University, Hangzhou 310058, China
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Abstract  Objective: Mitogen-activated protein kinases (MAPKs) are correlated with a more malignant phenotype in many cancers. This study was designed to evaluate the predictive value of the expression of MAPK phosphatase-1 (MKP-1) and phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), as the key regulatory mechanism of the MAPKs, in lung squamous cell carcinoma (SCC). Methods: We assessed the expressions of MKP-1 and p-ERK1/2 in twenty subjects at different differentiation degree of SCC and five normal lungs by immunohistochemistry and real-time reverse transcriptase polymerase chain reaction (RT-PCR) analysis. Results: Immunohistochemistry and real-time RT-PCR assay showed that the expression of MKP-1 was gradually decreased as tissue type went from normal lung tissues to increasingly undifferentiated carcinoma, and it was negatively correlated with tumor differentiation (P<0.01). However, the expression of p-ERK1/2 or ERK1/2 was gradually increased as tissue type went from normal lung tissues to increasingly undifferentiated carcinoma, and it was positively correlated with tumor differentiation (P<0.01). Conclusions: Our data indicates the relevance of MKP-1 and p-ERK1/2 in SCC as a potential positive and negative prognostic factor. The imbalanced expression of MKP-1 and p-ERK1/2 may play a role in the development of SCC and these two molecules may be new targets for the therapy and prognosis of SCC.

Key words： Mitogen-activated protein kinase phosphatase-1 (MKP-1)      Extracellular signal-regulated kinase (ERK)      Lung squamous cell carcinoma (SCC)      Prognostic factor     
Received: 20 May 2011      Published: 08 October 2011
CLC:  R734.2  
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Kai Wang
Min Zhang
Ying-ying Qian
Zhe-yuan Ding
Jun-hui Lv
Hua-hao Shen
Cite this article:

Kai Wang, Min Zhang, Ying-ying Qian, Zhe-yuan Ding, Jun-hui Lv, Hua-hao Shen. Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(10): 828-834.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1100165     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2011/V12/I10/828

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