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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2009, Vol. 10 Issue (3): 203-210    DOI: 10.1631/jzus.B0820213
Biomedicine     
Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats
He LI, Xiao-qing MA, Fan YE, Jing ZHANG, Xin ZHOU, Zhi-hong WANG, Yu-ming LI, Guo-yuan ZHANG
Cardiovascular Division, Department of Geriatric Medicine, Pingjin Hospital, Medical College of Chinese People’s Armed Police Force, Institute of Cardiovascular Disease of Chinese People’s Armed Police Force, Tianjin 300162, China; Cardiovascular Division, Changzheng Hospital, Shanghai 200003, China
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Abstract  Evidence suggests that the deterioration of communication between the sympathetic nervous system and cardiovascular system always accompanies the aging of human and animals. Cardiac sympathetic norepinephrine (NE) transporter (NET) on presynaptic membrane is a predominant component to eliminate released NE in the synaptic cleft and maintains the sensitivity of the β-adrenergic receptor (β-AR). In the present study, we investigated NET and β1-AR mRNA levels and sympathetic nerve density in cardiac sympathetic ganglion and left ventricular myocardium in 2- and 16-month-old rats with Northern blot analysis and immunohistochemistry. The expression levels of NET mRNA, NET protein and β1-AR mRNA in the ganglia or myocardia of 16-month-old rats were markedly reduced by 67%, 26%, and 43%, respectively, in comparison with those in 2-month-old rats. Our results also show that aging induces a strong decrease of the catecholaminergic nerve fiber density.

Key words： Norepinephrine transporter (NET)      β1-adrenergic receptor (β1-AR)      Cardiac sympathetic ganglion      Aging     
Received: 10 July 2008     
CLC:  R54  
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He LI
Xiao-qing MA
Fan YE
Jing ZHANG
Xin ZHOU
Zhi-hong WANG
Yu-ming LI
Guo-yuan ZHANG
Cite this article:

He LI, Xiao-qing MA, Fan YE, Jing ZHANG, Xin ZHOU, Zhi-hong WANG, Yu-ming LI, Guo-yuan ZHANG. Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2009, 10(3): 203-210.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820213     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2009/V10/I3/203

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