| Biomedicine |
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| Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment |
| DIMITROV Borislav D., ATANASSOVA Penka A., RACHKOVA Mariana I. |
| BORDANI, Alzano Lombardo, Bergamo 24022, Italy; Department of Neurology, Medical University, Plovdiv 4000, Bulgaria; ASSON-93 Research Co., Chicago, IL 60056, USA |
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Abstract This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.
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Received: 02 August 2007
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