| Biomedicine |
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| Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography |
| ZHANG Yan-zhen, ZHOU Yan-chun, LIU Li, ZHU Yan |
| Department of Stomatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Department of Stomatology, Hospital of Zhejiang University, Hangzhou 310027, China; Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; Department of Chemistry, Zhejiang University, Hangzhou 310028, China |
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Abstract Simple, reliable and sensitive analytical methods to determine anticariogenic agents, preservatives, and artificial sweeteners contained in commercial gargles are necessary for evaluating their effectiveness, safety, and quality. An ion chromatography (IC) method has been described to analyze simultaneously eight anions including fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate (anticariogenic agents), sorbate (a preservative), and saccharin (an artificial sweetener) in gargles. In this IC system, we applied a mobile phased gradient elution with KOH, separation by IonPac AS18 columns, and suppressed conductivity detection. Optimized analytical conditions were further evaluated for accuracy. The relative standard deviations (RSDs) of the inter-day’s retention time and peak area of all species were less than 0.938% and 8.731%, respectively, while RSDs of 5-day retention time and peak area were less than 1.265% and 8.934%, respectively. The correlation coefficients for targeted analytes ranged from 0.999 7 to 1.000 0. The spiked recoveries for the anions were 90%~102.5%. We concluded that the method can be applied for comprehensive evaluation of commercial gargles.
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Received: 09 May 2007
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Cite this article:
ZHANG Yan-zhen, ZHOU Yan-chun, LIU Li, ZHU Yan. Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(7): 507-511.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2007.B0507 OR http://www.zjujournals.com/xueshu/zjus-b/Y2007/V8/I7/507
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