生命科学 |
|
|
|
|
Math1基因在内耳毛细胞发育及再生过程中的作用 |
房冉1, 孟飞龙1, 李高鹏1, 饶琳1, 赵小立1,2 |
1.浙江大学 生命科学学院,浙江 杭州 310058 2.浙江省细胞与基因工程重点实验室,浙江 杭州 310058 |
|
Functions of Math1 in the inner ear hair cell development and regeneration |
FANG Ran1, MENG Feilong1, LI Gaopeng1, RAO Lin1, ZHAO Xiaoli1,2 |
1.College of Life Sciences, Zhejiang University, Hangzhou 310058, China 2.Zhejiang Provincial Key Laboratory for Cell and Gene Engineering, Hangzhou 310058, China |
引用本文:
房冉, 孟飞龙, 李高鹏, 饶琳, 赵小立. Math1基因在内耳毛细胞发育及再生过程中的作用[J]. 浙江大学学报(理学版), 2019, 46(1): 78-91.
FANG Ran, MENG Feilong, LI Gaopeng, RAO Lin, ZHAO Xiaoli. Functions of Math1 in the inner ear hair cell development and regeneration. Journal of ZheJIang University(Science Edition), 2019, 46(1): 78-91.
链接本文:
https://www.zjujournals.com/sci/CN/10.3785/j.issn.1008-9497.2019.01.010
或
https://www.zjujournals.com/sci/CN/Y2019/V46/I1/78
|
1 KELLEYM W, WUD K, POPPERA N, et al.Development of the Inner Ear[M]. New York:Springer, 2005. 2 MCFADDENS L, DINGD L, JIANGH Y, et al.Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla[J]. Brain Research, 2004, 997(1): 40-51. DOI: 10.1016/j.brainres.2003.10.031 3 MCGILLT J, SCHUKNECHTH F.Human cochlear changes in noise induced hearing loss[J]. Laryngoscope, 1976, 86(9): 1293-1302. DOI: 10.1288/00005537-197609000-00001 4 CAFARO, J, LEE G S,STONEJ S.Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration [J]. Devlopment Dynamics, 2007, 236(1): 156-170. DOI: 10.1002/dvdy.21023 5 JONESJ E, CORWINJ T.Regeneration of sensory cells after laser ablation in the lateral line system: Hair cell lineage and macrophage behavior revealed by time-lapse video microscopy[J]. The Journal of Neuroscience:the Official Journal of the Society for Neuroscience, 1996,16(2): 649-662. DOI: 10.1523/JNEUROSCI.16-02-00649.1996 6 CORWINJ T, OBERHOLTZERJ C.Fish n'Chicks: Model recipes minireview for hair-cell regeneration?[J]. Neuron,1997,91(5):951-954. DOI: 10.1016/S0896-6273(00)80386-4 7 RYALSB M, RUBELE W.Hair cell regeneration after acoustic trauma in adult Coturnix quail [J]. Science, 1988,240(4860):1774-1776. DOI: 10.1126/science.3381101 8 BLAMEYP, ARTIERESF, BASKENTD, et al.Factors affecting auditory performance of post linguistically deaf adults using cochlear implants: An update with 2251 patients[J]. Audiol Neurootol, 2012,18 (1):36-47. DOI: 10.1159/000343189 9 BLAMEYP J, DOOLEYG J, PARISIE S, et al.Pitch comparisons of acoustically and electrically evoked auditory sensations[J]. Hearing Research, 1996,99 (1/2):139-150. DOI: 10.1016/S0378-5955(96)00095-0 10 BRAMHALLN F, SHIF, ARNOLDK, et al. Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea[J]. Stem Cell Reports, 2014,2 (3):311-322. DOI: 10.1016/j.stemcr.2014.01.008 11 DOETZLHOFERA, BASCHM L, OHYAMAT, et al.Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti[J]. Developmental Cell, 2009,16 (1):58-69. DOI: 10.1016/j.devcel.2008.11.008 12 TAKEBAYASHIS,YAMAMOTON, YABED, et al.Multiple roles of Notch signaling in cochlear development[J]. Developmental Biology, 2007,307(1):165-178. DOI: 10.1016/j.ydbio.2007.04.035 13 WHITEP M, DOETZLHOFERA, LEE Y S, et al.Mamma-lian cochlear supporting cells can divide and transdifferentiate into hair cells[J]. Nature, 2006,441(7096):984-987. DOI: 10.1038/nature04849 14 LIUZ, OWENT, FANGJ,et al.In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation[J]. Developwent Dynamics, 2012,241(4):684-696. DOI: 10.1002/dvdy.23863 15 MAASSJ C, GUR, BASCHM L, et al. Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea[J]. Frontiers in Cellular Neuroscience, 2015, 9(110):1-14. DOI: 10.3389/fncel.2015.00110 16 YANGS M, CHENW, GUOW W, et al.Regeneration of stereocilia of hair cells by forced Atoh1 expression in the adult mammalian cochlea[J]. Plos One, 2012, 7(9): e46355. DOI: 10.1371/journal.pone.0046355 17 BERMINGHAMN A, HASSANB A,PRICES D, et al.Math1: An essential gene for the generation of inner ear hair cells[J]. Science, 1999, 284(5421): 1837-1841. DOI: 10.1126/science.284.5421.1837 18 GUBBELSS P, WOESSNERD W, MITCHELLJ C, et al. Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer[J]. Nature, 2008, 455(7212): 537-541. DOI: 10.1038/nature07265 19 IZUMIKAWAM, MINODAR, KAWAMOTOK, et al.Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals[J]. Nature Medicine, 2005, 11(3): 271-276. DOI: 10.1038/nm1193 20 PANN, JAHANI, KERSIGOJ, et al.A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability[J]. Plos One, 2012, 7(1): e30358. DOI: 10.1371/journal.pone.0030358 21 ZHENGJ L, GAOW Q.Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears[J]. Nature Neuroscience, 2000, 3(6): 580-586. DOI: 10.1038/75753 22 KAWAMOTOK, ISHIMOTOS, MINODAR, et al.Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo[J]. The Journal of Neuroscience, 2003, 23(11): 4395-4400. DOI: 10.1523/JNEUROSCI.23-11-04395.2003 23 SUNJ H,YANGS M.Histology of the Ear[M]. Beijing:People's Military Medical Press,2015. 24 LITSIOUA, HANSONS, STREITA. A balance of FGF, BMP and WNT signalling positions the future placode territory in the head[J]. Development, 2005,132(18):4051-4062. DOI: 10.1242/dev.01964 25 COTANCHED A, KAISERC L.Hair cell fate decisions in cochlear development and regeneration[J].Hearing Research, 2010, 266(1/2): 18-25. DOI: 10.1016/j.heares.2010.04.012 26 MULVANEYJ,DANDOUBA.Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: Function, regulation, and context dependency[J]. Journal of the Association Research in Otolaryngol, 2012,13(3): 281-293. DOI: 10.1007/s10162-012-0317-4 27 LEE Y S, LIUF, SEGILN.A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development[J]. Development, 2006,133(15): 2817-2826. DOI: 10.1242/dev.02453 28 RUBENR J.Development of the inner ear of the mouse: A radioautographic study of terminal mitoses [J]. Acta Otolaryngol, 1967, 220: 1-44. 29 STOJANOVAZ P, KWANT, SEGILN.Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea[J]. Development, 2015, 142(20): 3529-3536. DOI: 10.1242/dev.126763 30 DRIVERE C, SILLERSL, COATET M, et al.The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea[J]. Development Biology, 2013,376(1): 86-98. DOI: 10.1016/j.ydbio.2013.01.005 31 ZAK M, KLISS F, GROLMANW.The Wnt and Notch signalling pathways in the developing cochlea: Formation of hair cells and induction of regenerative potential[J]. International Journal of Developmental Neuroscience, 2015, 47: 247-258. DOI: 10.1016/j.ijdevneu.2015.09.008 32 CAIT, SEYMOURM L, ZHANGH,et al.Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti[J]. Journal of Neurosci, 2013, 33(24): 10110-10122. DOI: 10.1523/JNEUROSCI.5606-12.2013 33 CHONOKOK T, JAHANI, STONEJ, et al.Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear[J]. Development Biology, 2013,381(2):401-410. DOI: 10.1016/j.ydbio.2013.06.022 34 OH S H, JOHNSONR, WUD K.Differential expression of bone morphogenetic proteins in the developing vestibular and auditory sensory organs[J]. Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 1996, 16(20): 6463-6475. DOI: 10.1523/JNEUROSCI.16-20-06463.1996 35 MORSLIH, CHOOD, RYANA, et al.Development of the mouse inner ear and origin of its sensory organs[J]. Journal of Neuroscience, 1998, 18(9): 3327-3335. DOI: 10.1523/JNEUROSCI.18-09-03327.1998 36 PUJADESC, KAMAIDA, ALSINAB.BMP-signaling regulates the generation of hair cells[J]. Developmental Biology, 2006, 292(1): 55-67. DOI: 10.1016/j.ydbio.2006.01.001 37 KATAGIRIT, IMADAM, YANAIT.Identification of a BMP-responsive element in Id1, the gene for inhib- ition of myogenesis[J]. Genes to Cells, 2002, 7(9): 949- 960. DOI: 10.1046/j.1365-2443.2002.00573.x 38 KAMAIDA, NEVESJ, GIRáLDEZF.Id gene regulation and function in the prosensory domains of the chicken inner ear: A link between Bmp signaling and Atoh1[J]. Journal of Neuroscience, 2010,30(34): 11426-11434. DOI: 10.1523/JNEUROSCI.2570-10.2010 39 SHINM, OHTES, FUKUDAT, et al.Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes[J]. Journal of Bone and Mineral Metabolism, 2013, 31(1): 34-43. DOI: 10.1007/S00774-012-0381-1 40 JONESJ M, MONTCOUQUIOLM, DABDOUBA,et al.Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2006, 26(2): 550-558. DOI: 10.1523/JNEUROSCI.3859-05.2006 41 WRIGHTT J,MANSOURS L.FGF signaling in ear development and innervation[J]. Current Topics in Developmental Biology, 2003, 57(12): 225-259. DOI: 10.1016/S0070-2153(03)57008-9 42 MILLIMAKIB B, SWEETE M, DHASONM S, et al.Zebrafish atoh1 genes: Classic pro-neural activity in the inner ear and regulation by Fgf and Notch[J]. Development, 2007, 134(2): 295-305. DOI: 10.1242/dev.02734 43 HAYASHIT, RAY C A, BERMINGHAM-MCDONOGHO.Fgf20 is required for sensory epithelial specification in the developing cochlea[J]. Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2008, 28 (23): 5991-5999. DOI: 10.1523/JNEUROSCI.1690-08.2008 44 PIRVOLAU,YLIKOSKIJ, TROKOVICR, et al.FGFR 1 is required for the development of the auditory sensory epithelium[J]. Neuron, 2002, 35(4): 671-680. DOI: 10.1016/S0896-6273(02)00824-3 45 BROOKERR , HOZUMI K LEWISJ. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear[J]. Development, 2006, 133(7): 1277-1286. DOI: 10.1242/dev.02284 46 LANFORDP J, LANY, JIANGR L, et al.Notch signalling pathway mediates hair cell development in mammalian cochlea[J]. Nature Genetics, 1999, 21(3): 289-292. DOI: 10.1038/6804 47 YANGH, XIEX, DENGM.Generation and characterization of Atoh1-Cre knock-in mouse line[J]. Genesis, 2010, 48(6): 407-413. DOI: 10.1002/dvg.20633 48 MATEIV, PAULEYS, KAINGS ,et al.Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell terminal mitosis[J]. Developmental Dynamics, 2005, 234(3): 633-650. DOI: 10.1002/dvdy.20551 49 ABDOLAZIMIY, STOJANOVAZ, SEGILN.Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter[J]. Development, 2016, 143(5): 841-850. DOI: 10.1242/dev.129320 50 JARRIAULTS, BROUC,LOGEATF, et al.Signalling downstream of activated mammalian Notch [J]. Nature, 1995, 377(6547): 355-358. DOI: 10.1038/377355a0 51 NISHIMURAM, ISAKAF, ISHIBASHIM, et al.Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of drosophila hairy and enhancer of split[J]. Genomics, 1998, 49(1): 69-75. DOI: 10.1006/geno.1998.5213 52 OHTSUKAT, ISHIBASHIM, GRADWOHLG, et al. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation[J]. The EMBO Journal, 1999, 18(8): 2196-2207. DOI: 10.1093/emboj/18.8.2196 53 HAYASHIT, KOKUBOH, HARTMANB H, et al.Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea[J]. Developmental Biology, 2008, 316(1): 87-99. DOI: 10.1016/j.ydbio.2008.01.006 54 LIS D, MARKS, RADDE-GALLWITZK, et al.Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development[J]. BMC Dev Biol, 2008,8:20. DOI:10.1186/1471-213X-8-20 55 SHIF, CHENGY F, WANGX L, et al.Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhance[J]. Journal of Biological Chemistry, 2010, 285(1): 392-400. DOI: 10.1074/jbc.M109.059055 56 AGATHOCLEOUSM, IORDANOVAI, WILLARDSENM I, et al.A directional Wnt/beta-catenin-Sox2-proneural path-way regulates the transition from proliferation to differentiation in the Xenopus retina[J]. Development, 2009, 136(19): 3289-3299. DOI: 10.1242/dev.040451 57 JAYASENAC S, OHYAMAT, SEGILN, et al.Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode[J]. Development, 2008, 135(13): 2251-2261. DOI: 10.1242/dev.017905 58 JACQUESB E, PULIGILLAC, WEICHERTR M, et al.A dual function for canonical wnt/ β-catenin signaling in the developing mammal- ian cochlea[J]. Development, 2013, 140(1): 247-247. DOI: 10.1242/dev.080358 59 SHIF, HUL, JACQUESB E, et al.β-catenin is required for hair-cell differentiation in the cochlea [J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2014, 34(19): 6470-6479. DOI: 10.1523/JNEUROSCI.4305-13.2014 60 KUO B R, BALDWINE M, LAYMANW S, et al.In vivo cochlear hair cell generation and survival by coactivation of β-catenin and Atoh1[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2015, 35(30): 10786-10798. DOI: 10.1523/JNEUROSCI.0967-15.2015 61 NAKAMURAT, NAKAMURAT, MATSUMOTOK.The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology [J]. Journal of Cellular and Molecular Medicine, 2008,12(2): 391-408. DOI: 10.1111/j.1582-4934.2007.00201.x 62 MULVANEYJ F, THOMPKINSC, NODAT, et al.Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line[J]. Scientific Reports, 2016, 6:31668. DOI: 10.1038/srep31668 63 CHAIR, KUO B, WANGT, et al.Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea [J]. Proceedings of the National Academy of Scieces of the USA, 2012, 109(21):8167-8172. DOI: 10.1073/pnas.1202774109 64 ESTRACHS, AMBLERC A, CELSOC L L, et al.Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis[J]. Development, 2006, 133(22):4427-4438. DOI: 10.1242/dev.02644 65 PANNEQUINJ, BONNANSC, DELAUNAYN, et al.The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells[J]. Cancer Res, 2009,69(15): 6065-6073. DOI: 10.1158/0008-5472.CAN-08-2409 66 KATOHM, KATOHM.Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells[J]. Internationai Journal of Molecular Medicine, 2006, 17: 681-685. DOI: 10.3892/ijmm.17.4.681 67 COLLUG M, HIDALGO-SASTREA, ACARA, et al.Dishevelled limits Notch signalling through inhibition of CSL[J]. Development, 2012, 139(23): 4405-4415. DOI: 10.1242/dev.081885 68 DAVIESA, FORMSTONEC, MASONI, et al.Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-flamingo -1 protein [J]. Developmental Dynamics, 2005, 233(3): 998-1005. DOI: 10.1002/dvdy.20376 69 JAHANI, PANN, FRITZSCHB.Opportunities and limits of the one gene approach: The ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context[J]. Frontiers in Cellular Neuroscience, 2015,9: 26. DOI: 10.3389/fncel.2015.00026 70 KIERNANA E, PELLINGA L, LEUNGK K, et al.Sox2 is required for sensory organ development in the mammalian inner ear[J]. Nature, 2005,434(7036): 1031- 1035. DOI: 10.1038/nature03487 71 BOUCHARDM, CAPRONAD D, BUSSLINGERM, et al.Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation [J]. Bmc Developmental Biology, 2010, 10(1):89. DOI: 10.1186/1471-213X-10-89 72 ZOUD, SILVIUSD, FRITZSCHB, et al. Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes[J]. Development, 2004,131 (22): 5561-5572. DOI: 10.1242/dev.01437 73 NEVESJ, VACHKOVI, GIRALDEZF.Sox2 regulation of hair cell development: Incoherence makes sense[J]. Hearing Research, 2013, 297(2): 20-29. DOI: 10.1016/j.heares.2012.11.003 74 NEVESJ, PARADAC, CHAMIZOM, et al.Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: A mechanism for sensory organ specification[J]. Development, 2011,138(4):735-744. DOI: 10.1242/dev.060657 75 KEMPFLEJ S, TURBANJ L, EDGEA S B.Sox2 in the differentiation of cochlear progenitor cells[J]. Scientific Reports, 2016, 6: 23293. DOI:10.1038/srep23293 76 NEVESJ, KAMAIDA, ALSINAB, et al.Differential expression of Sox2 and Sox3 in neuronal and sensory progenitors of the developing inner ear of the chick[J]. Journal of Comparative Neurology, 2007,503(4):487-500. DOI: 10.1002/cne.21299 77 OESTERLEE C, CAMPBELLS, TAYLORR R, et al. Sox2 and Jagged1 expression in normal and drug-damaged adult mouse inner ear[J]. Journal of the Association for Research in Otolaryngology, 2008, 9(1): 65-89. DOI:10.1007/s10162-007-0106-7 78 WALLISD, HAMBLENM, ZHOUY.The zinc finger transcription factor Gfi1, implicated in lymphoma-genesis, is required for inner ear hair cell differentiation and survival[J]. Development, 2003,130(1): 221-232. DOI: 10.1242/dev.00190 79 KIRJAVAINENA, SULGM, HEYDF, et al.Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia[J]. Developmental Biology, 2008, 322(1): 33-45. DOI: 10.1016/j.ydbio.2008.07.004 80 SCHEFFERD I,SHENJ, COREYD P, alet, Gene expression by mouse inner ear hair cells during development[J].Journal of Neurosci, 2015, 35(16): 6366-6380. DOI: 10.1523/JNEUROSCI.5126-14.2015 81 COSTAA, POWELLL M, LOWELLS, et al.Atoh1 in sensory hair cell development: Constraints and cofactors[J]. Seminars in Cell and Developmental Biology, 2017, 65: 60-68. DOI: 10.1016/j.semcdb.2016.10.003 82 HERTZANOR, MONTCOUQUIOLM, RASHI-ELKELESS, et al.Transcription profiling of inner ears from Pou4f3 (ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene[J]. Human Molecular Genetics, 2004, 13(18): 2143-2153. DOI: 10.1093/hmg/ddh218 83 XIANGM, GAOW Q, HASSONT, et al.Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells[J]. Development, 1998,125(20): 3935-3946. 84 XIANGM, ZHOUL, MACKEJ P, et al.The Brn-3 family of POU-domain factors: Primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons[J]. Journal of Neuroscience, 1995,15:4762-4785. DOI: 10.1523/JNEUROSCI.15-07-04762.1995 85 XIANGM Q, GANL, LID Q,et al. Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development[J]. Proceedings of the National Academy of Sciences of the USA, 1997, 94(17): 9445-9450. DOI: 10.1073/pnas.94.17.9445 86 MASUDAM, DULOND, PAK K, et al.Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice[J]. Neuroscience, 2011, 197: 48-64. DOI: 10.1016/j.neuroscience.2011.09.033 87 LIUZ, FANGJ, DEARMANJ, et al.In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression[J]. Plos One, 2014, 9(2):e89377. DOI: 10.1371/journal.pone.0089377 88 MASUDAM, LIY, PAK K, et al.The promoter and multiple enhancers of the pou4f3 gene Regulate expression in inner ear hair cells[J]. Molecular Neurobiology, 2017,54(7):5414-5426. DOI: 10.1007/s12035-016-0060-7 89 LIUM, PEREIRAF A, PRICES D, et al. Essential role of BETA2/NeuroD1 in development of the vesti- bular and auditory systems[J]. Genes Dev, 2000, 14(22): 2839-2854. DOI: 10.1101/gad.840500 90 LEE J K, CHO J H, HWANGW S, et al.Expression of NeuroD/BETA2 in mitotic and postmitotic neuronal cells during the development of nervous system [J]. Developmental Dynamics, 2000, 217(4): 361-367. DOI: 10.1002/(SICI)1097-0177(200004)217:4<361::AID-DVDY3>3.0.CO;2-8 91 NAYAF J, HUANGH P, QIUY H, et al.Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuro D-deficient Mice[J]. Genes and Development, 1997, 11(18): 2323-2334. DOI: 10.1101/gad.11.18.2323 92 JAHANI, PANN, KERSIGOJ, et al.Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea[J]. Plos One, 2010,5(7): e11661. DOI: 10.1371/journal.pone.0011661 93 RAFTS, KOUNDAKJIANE J, QUINONESH, et al.Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development[J]. Development, 2007,134 (24): 4405-4415. DOI: 10.1242/dev.009118 94 BANNISTERA J, ZEGERMANP, PARTRIDGEJ F, et al.Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain[J]. Nature, 2001, 410(6824): 120-124. DOI: 10.1038/35065138 95 BERNSTEINB E, MIKKELSENT S, XIEX H, et al.A bivalent chromatin structure marks key developmental genes in embryonic stem cells[J]. Cell, 2006, 125(2): 315-326. DOI: 10.1016/j.cell.2006.02.041 96 KARMODIYAK, KREBSA R, OULAD-ABDELGHANIM, et al.H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells[J]. Bmc Genomics, 2012, 13: 424. DOI: 10.1186/1471-2164-13-424 97 RUDNICKIA, AVRAHAMK B.MicroRNAs: The art of silencing in the ear[J]. Embo Molecular Medicine, 2012,4(9): 849-859. DOI: 10.1002/emmm.201100922 98 MENCíAA, MODAMIO-H?YBJ?RS, REDSHAWN, et al. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss[J]. Nature Genetics, 2009, 41(5): 609-613. DOI: 10.1038/ng.355 99 EBEIDM, SRIPALP, PECKAJ, et al.Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells[J]. Plos One, 2017,12 (7):e0180855. DOI: 10.1371/journal.pone.0180855 100 STONEJ S, COTANCHED A.Identification of the timing of S phase and the patterns of cell proliferation during hair cell regeneration in the chick cochlea[J]. Journal of Comparative Neurology, 1994, 341(1): 50-67. DOI: 10.1002/cne.903410106 101 CAFAROJ, LEE G S, STONEJ S. Atoh1 expre- ssion defines activated progenitors and differentiating hair cells during avian hair cell regeneration [J]. Developmental Dynamics,2007,236(1):156-170. DOI: 10.1002/dvdy.21023 102 LUSHM E, PIOTROWSKIT.Sensory hair cell regeneration in the zebrafish lateral line[J]. Developmental Dynamics, 2014,243(10): 1187-11202. DOI: 10.1002/dvdy.24167 103 JACQUESB E, MONTGOMERYW H, URIBEPM, et al.The role of Wnt/beta-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line[J]. Developmental Neurobiology, 2014,74(4):438-456. DOI: 10.1002/dneu.22134 104 JIANGL, ROMERO-CARVAJALA, HAUGJ S,et al.Gene-expression analysis of hair cell regeneration in the zebrafish lateral line[J]. Proceedings of the National Academay of Sciences of the USA, 2014,111(14): 1383–1392. DOI: 10.1073/pnas.1402898111 105 DAUDETN, GIBSONR, SHANGJ, et al.Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds[J]. Developmental Biology, 2009, 326(1): 86-100. DOI: 10.1016/j.ydbio.2008.10.033 106 MA E Y, RUBELE W, RAIBLED W.Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line[J]. Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2008, 28(9): 2261-2273. DOI: 10.1523/JNEUROSCI.4372-07.2008 107 OUJIY, ISHIZAKAS, NAKAMURA-UCHIYAMAF, alet, Induction of inner ear hair cell-like cells from Math1-transfected mouse ES cells[J]. Cell Death and Disease,2013, 4(7): e700. DOI: 10.1038/cddis.2013.230 108 RONAGHIM, NASRM, EALYM, et al.Inner ear hair cell-like cells from human embryonic stem cells[J]. Stem Cells and and Development, 2014, 23(11): 1275-1284. DOI: 10.1089/scd.2014.0033 109 RICHARDSONR T, ATKINSONP J.Atoh1 gene therapy in the cochlea for hair cell regeneration[J]. Expert Opin Biol Ther, 2015.15(3): 417-430. DOI: 10.1517/14712598.2015.1009889 110 WALTERSB J, COAKE, DEARMANJ, et al.In vivo interplay between p27Kip1, GATA3, ATOH1, and POU4F3 converts non-sensory cells to hair cells in adult mice [J]. Cell Reports, 2017, 19(2): 307-320. DOI:10.1016/j.celrep.2017.03.044 111 BURNSJ C, COX B C, THIEDEB R, et al.In vivo proliferative regeneration of balance hair cells in newborn mice[J]. Journal of Neuroscience, 2012, 32(19): 6570-6577. DOI: 10.1523/JNEUROSCI.6274-11.2012 112 JUNGJ Y, AVENARIUSM R, ADAMSKYS, et al.SiRNA targeting Hes5 augments hair cell regeneration in aminoglycoside-damaged mouse utricle[J]. Molecular Therapy, 2013, 21(4): 834-841. DOI: 10.1038/mt.2013.18 113 LINV, GOLUBJ S, NGUYENT B, et al.Inhibition of notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2011, 31(43): 15329-15339. DOI: 10.1523/JNEUROSCI.2057-11.2011 114 YAMAMOTON, TANIGAKIK, TSUJIM, et al.Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas[J]. Journal of Molecular Medicine, 2006, 84(1): 37-45. DOI: 10.1007/s00109-005-0706-9 115 LIW Y , WUJ F, YANGJ M, et al.Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway[J]. PNAS, 2015,112(1): 166-171. DOI: 10.1073/pnas.1415901112 116 SHIF X, HUL X, EDGEA S.Generation of hair cells in neonatal mice by beta-catenin overexpression in Lgr5-positive cochlear progenitors[J]. Proceedings of the National Academy of Science of the USA, 2013, 110(34):13851-13856. DOI: 10.1073/pnas.1219952110 117 SHIF, KEMPFLEJ S, EDGEA S.Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2012,32(28): 9639- 9648. DOI: 10.1523/JNEUROSCI.1064-12.2012 118 CHAIR, XIAA, WANGT, et al.Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea [J]. Journal of the Association for Research in Otolaryngology, 2011,12(4): 455-469. DOI: 10.1007/s10162-011-0267-2 119 COSTAA, SANCHEZ-GUARDADOL, JUNIATS, et al.Generation of sensory hair cells by genetic programming with a combination of transcription factors [J]. Development, 2015, 142(11): 1948-1959. DOI: 10.1242/dev.119149 120 IKEDAR, PAK K, CHAVEZE, et al.Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells[J]. Molecular Neurobiology, 2015, 51(2): 672-684. DOI: 10.1007/s12035-014-8801-y 121 MASUDAM, PAK K, CHAVEZE, et al.TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1[J]. Developmental Biology, 2012, 372(1): 68-80. DOI: 10.1016/j.ydbio.2012.09.002 |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|