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浙江大学学报(理学版)  2019, Vol. 46 Issue (1): 78-91    DOI: 10.3785/j.issn.1008-9497.2019.01.010
生命科学     
Math1基因在内耳毛细胞发育及再生过程中的作用
房冉1, 孟飞龙1, 李高鹏1, 饶琳1, 赵小立1,2
1.浙江大学 生命科学学院,浙江 杭州 310058
2.浙江省细胞与基因工程重点实验室,浙江 杭州 310058
Functions of Math1 in the inner ear hair cell development and regeneration
FANG Ran1, MENG Feilong1, LI Gaopeng1, RAO Lin1, ZHAO Xiaoli1,2
1.College of Life Sciences, Zhejiang University, Hangzhou 310058, China
2.Zhejiang Provincial Key Laboratory for Cell and Gene Engineering, Hangzhou 310058, China
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摘要: 耳蜗感觉毛细胞作为听觉机械感受器,在听觉的发生过程中起着至关重要的作用。 哺乳动物的毛细胞损伤后无法再生,往往会造成听力障碍或永久性听力缺失。因此,阐明内耳感觉毛细胞发育过程中的分子机制对听力损伤的诊断与治疗具有非常重要的意义。Math1是毛细胞发育与再生过程中的关键基因,本文就Math1及其相关基因和信号通路在毛细胞的发育与再生过程中的调控作用做简要概述。
关键词: 转录因子Math1毛细胞发育再生    
Abstract: Cochlear sensory hair cells, as auditory mechanoreceptor, are the linchpin of our senses of hearing. The inability of the mammalian inner ear to regenerate lost hair cells is the major reason for the hearing disorder or permanent hearing loss. So elucidating the mechanisms of the mammalian inner ear development will be useful for testing potential inner ear therapies. Transcription factor Math1 plays an important role in the process of the hair cells development and regeneration. This paper provides an overview of the functions of Math1 and its related genes or signaling pathways in this process.
Key words: transcription factor    Math1    hair cells    development    regeneration
收稿日期: 2017-11-30 出版日期: 2019-01-25
CLC:  Q 78  
基金资助: 国家重点基础研究发展规划(973计划)项目(2012CB967900).
作者简介: 房 冉(1992—),ORCID:http://orcid. org / 0000-0003-2410-5926,女 ,硕 士 研 究 生 ,主 要 从 事 干 细 胞 分 化 研 究 ,E-mail:fangran@zju.edu.cn.
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引用本文:

房冉, 孟飞龙, 李高鹏, 饶琳, 赵小立. Math1基因在内耳毛细胞发育及再生过程中的作用[J]. 浙江大学学报(理学版), 2019, 46(1): 78-91.

FANG Ran, MENG Feilong, LI Gaopeng, RAO Lin, ZHAO Xiaoli. Functions of Math1 in the inner ear hair cell development and regeneration. Journal of ZheJIang University(Science Edition), 2019, 46(1): 78-91.

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https://www.zjujournals.com/sci/CN/10.3785/j.issn.1008-9497.2019.01.010        https://www.zjujournals.com/sci/CN/Y2019/V46/I1/78

1 KELLEYM W, WUD K, POPPERA N, et al.Development of the Inner Ear[M]. New York:Springer, 2005.
2 MCFADDENS L, DINGD L, JIANGH Y, et al.Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla[J]. Brain Research, 2004, 997(1): 40-51. DOI: 10.1016/j.brainres.2003.10.031
3 MCGILLT J, SCHUKNECHTH F.Human cochlear changes in noise induced hearing loss[J]. Laryngoscope, 1976, 86(9): 1293-1302. DOI: 10.1288/00005537-197609000-00001
4 CAFARO, J, LEE G S,STONEJ S.Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration [J]. Devlopment Dynamics, 2007, 236(1): 156-170. DOI: 10.1002/dvdy.21023
5 JONESJ E, CORWINJ T.Regeneration of sensory cells after laser ablation in the lateral line system: Hair cell lineage and macrophage behavior revealed by time-lapse video microscopy[J]. The Journal of Neuroscience:the Official Journal of the Society for Neuroscience, 1996,16(2): 649-662. DOI: 10.1523/JNEUROSCI.16-02-00649.1996
6 CORWINJ T, OBERHOLTZERJ C.Fish n'Chicks: Model recipes minireview for hair-cell regeneration?[J]. Neuron,1997,91(5):951-954. DOI: 10.1016/S0896-6273(00)80386-4
7 RYALSB M, RUBELE W.Hair cell regeneration after acoustic trauma in adult Coturnix quail [J]. Science, 1988,240(4860):1774-1776. DOI: 10.1126/science.3381101
8 BLAMEYP, ARTIERESF, BASKENTD, et al.Factors affecting auditory performance of post linguistically deaf adults using cochlear implants: An update with 2251 patients[J]. Audiol Neurootol, 2012,18 (1):36-47. DOI: 10.1159/000343189
9 BLAMEYP J, DOOLEYG J, PARISIE S, et al.Pitch comparisons of acoustically and electrically evoked auditory sensations[J]. Hearing Research, 1996,99 (1/2):139-150. DOI: 10.1016/S0378-5955(96)00095-0
10 BRAMHALLN F, SHIF, ARNOLDK, et al. Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea[J]. Stem Cell Reports, 2014,2 (3):311-322. DOI: 10.1016/j.stemcr.2014.01.008
11 DOETZLHOFERA, BASCHM L, OHYAMAT, et al.Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti[J]. Developmental Cell, 2009,16 (1):58-69. DOI: 10.1016/j.devcel.2008.11.008
12 TAKEBAYASHIS,YAMAMOTON, YABED, et al.Multiple roles of Notch signaling in cochlear development[J]. Developmental Biology, 2007,307(1):165-178. DOI: 10.1016/j.ydbio.2007.04.035
13 WHITEP M, DOETZLHOFERA, LEE Y S, et al.Mamma-lian cochlear supporting cells can divide and transdifferentiate into hair cells[J]. Nature, 2006,441(7096):984-987. DOI: 10.1038/nature04849
14 LIUZ, OWENT, FANGJ,et al.In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation[J]. Developwent Dynamics, 2012,241(4):684-696. DOI: 10.1002/dvdy.23863
15 MAASSJ C, GUR, BASCHM L, et al. Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea[J]. Frontiers in Cellular Neuroscience, 2015, 9(110):1-14. DOI: 10.3389/fncel.2015.00110
16 YANGS M, CHENW, GUOW W, et al.Regeneration of stereocilia of hair cells by forced Atoh1 expression in the adult mammalian cochlea[J]. Plos One, 2012, 7(9): e46355. DOI: 10.1371/journal.pone.0046355
17 BERMINGHAMN A, HASSANB A,PRICES D, et al.Math1: An essential gene for the generation of inner ear hair cells[J]. Science, 1999, 284(5421): 1837-1841. DOI: 10.1126/science.284.5421.1837
18 GUBBELSS P, WOESSNERD W, MITCHELLJ C, et al. Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer[J]. Nature, 2008, 455(7212): 537-541. DOI: 10.1038/nature07265
19 IZUMIKAWAM, MINODAR, KAWAMOTOK, et al.Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals[J]. Nature Medicine, 2005, 11(3): 271-276. DOI: 10.1038/nm1193
20 PANN, JAHANI, KERSIGOJ, et al.A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability[J]. Plos One, 2012, 7(1): e30358. DOI: 10.1371/journal.pone.0030358
21 ZHENGJ L, GAOW Q.Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears[J]. Nature Neuroscience, 2000, 3(6): 580-586. DOI: 10.1038/75753
22 KAWAMOTOK, ISHIMOTOS, MINODAR, et al.Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo[J]. The Journal of Neuroscience, 2003, 23(11): 4395-4400. DOI: 10.1523/JNEUROSCI.23-11-04395.2003
23 SUNJ H,YANGS M.Histology of the Ear[M]. Beijing:People's Military Medical Press,2015.
24 LITSIOUA, HANSONS, STREITA. A balance of FGF, BMP and WNT signalling positions the future placode territory in the head[J]. Development, 2005,132(18):4051-4062. DOI: 10.1242/dev.01964
25 COTANCHED A, KAISERC L.Hair cell fate decisions in cochlear development and regeneration[J].Hearing Research, 2010, 266(1/2): 18-25. DOI: 10.1016/j.heares.2010.04.012
26 MULVANEYJ,DANDOUBA.Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: Function, regulation, and context dependency[J]. Journal of the Association Research in Otolaryngol, 2012,13(3): 281-293. DOI: 10.1007/s10162-012-0317-4
27 LEE Y S, LIUF, SEGILN.A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development[J]. Development, 2006,133(15): 2817-2826. DOI: 10.1242/dev.02453
28 RUBENR J.Development of the inner ear of the mouse: A radioautographic study of terminal mitoses [J]. Acta Otolaryngol, 1967, 220: 1-44.
29 STOJANOVAZ P, KWANT, SEGILN.Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea[J]. Development, 2015, 142(20): 3529-3536. DOI: 10.1242/dev.126763
30 DRIVERE C, SILLERSL, COATET M, et al.The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea[J]. Development Biology, 2013,376(1): 86-98. DOI: 10.1016/j.ydbio.2013.01.005
31 ZAK M, KLISS F, GROLMANW.The Wnt and Notch signalling pathways in the developing cochlea: Formation of hair cells and induction of regenerative potential[J]. International Journal of Developmental Neuroscience, 2015, 47: 247-258. DOI: 10.1016/j.ijdevneu.2015.09.008
32 CAIT, SEYMOURM L, ZHANGH,et al.Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti[J]. Journal of Neurosci, 2013, 33(24): 10110-10122. DOI: 10.1523/JNEUROSCI.5606-12.2013
33 CHONOKOK T, JAHANI, STONEJ, et al.Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear[J]. Development Biology, 2013,381(2):401-410. DOI: 10.1016/j.ydbio.2013.06.022
34 OH S H, JOHNSONR, WUD K.Differential expression of bone morphogenetic proteins in the developing vestibular and auditory sensory organs[J]. Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 1996, 16(20): 6463-6475. DOI: 10.1523/JNEUROSCI.16-20-06463.1996
35 MORSLIH, CHOOD, RYANA, et al.Development of the mouse inner ear and origin of its sensory organs[J]. Journal of Neuroscience, 1998, 18(9): 3327-3335. DOI: 10.1523/JNEUROSCI.18-09-03327.1998
36 PUJADESC, KAMAIDA, ALSINAB.BMP-signaling regulates the generation of hair cells[J]. Developmental Biology, 2006, 292(1): 55-67. DOI: 10.1016/j.ydbio.2006.01.001
37 KATAGIRIT, IMADAM, YANAIT.Identification of a BMP-responsive element in Id1, the gene for inhib- ition of myogenesis[J]. Genes to Cells, 2002, 7(9): 949- 960. DOI: 10.1046/j.1365-2443.2002.00573.x
38 KAMAIDA, NEVESJ, GIRáLDEZF.Id gene regulation and function in the prosensory domains of the chicken inner ear: A link between Bmp signaling and Atoh1[J]. Journal of Neuroscience, 2010,30(34): 11426-11434. DOI: 10.1523/JNEUROSCI.2570-10.2010
39 SHINM, OHTES, FUKUDAT, et al.Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes[J]. Journal of Bone and Mineral Metabolism, 2013, 31(1): 34-43. DOI: 10.1007/S00774-012-0381-1
40 JONESJ M, MONTCOUQUIOLM, DABDOUBA,et al.Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2006, 26(2): 550-558. DOI: 10.1523/JNEUROSCI.3859-05.2006
41 WRIGHTT J,MANSOURS L.FGF signaling in ear development and innervation[J]. Current Topics in Developmental Biology, 2003, 57(12): 225-259. DOI: 10.1016/S0070-2153(03)57008-9
42 MILLIMAKIB B, SWEETE M, DHASONM S, et al.Zebrafish atoh1 genes: Classic pro-neural activity in the inner ear and regulation by Fgf and Notch[J]. Development, 2007, 134(2): 295-305. DOI: 10.1242/dev.02734
43 HAYASHIT, RAY C A, BERMINGHAM-MCDONOGHO.Fgf20 is required for sensory epithelial specification in the developing cochlea[J]. Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2008, 28 (23): 5991-5999. DOI: 10.1523/JNEUROSCI.1690-08.2008
44 PIRVOLAU,YLIKOSKIJ, TROKOVICR, et al.FGFR 1 is required for the development of the auditory sensory epithelium[J]. Neuron, 2002, 35(4): 671-680. DOI: 10.1016/S0896-6273(02)00824-3
45 BROOKERR , HOZUMI K LEWISJ. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear[J]. Development, 2006, 133(7): 1277-1286. DOI: 10.1242/dev.02284
46 LANFORDP J, LANY, JIANGR L, et al.Notch signalling pathway mediates hair cell development in mammalian cochlea[J]. Nature Genetics, 1999, 21(3): 289-292. DOI: 10.1038/6804
47 YANGH, XIEX, DENGM.Generation and characterization of Atoh1-Cre knock-in mouse line[J]. Genesis, 2010, 48(6): 407-413. DOI: 10.1002/dvg.20633
48 MATEIV, PAULEYS, KAINGS ,et al.Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell terminal mitosis[J]. Developmental Dynamics, 2005, 234(3): 633-650. DOI: 10.1002/dvdy.20551
49 ABDOLAZIMIY, STOJANOVAZ, SEGILN.Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter[J]. Development, 2016, 143(5): 841-850. DOI: 10.1242/dev.129320
50 JARRIAULTS, BROUC,LOGEATF, et al.Signalling downstream of activated mammalian Notch [J]. Nature, 1995, 377(6547): 355-358. DOI: 10.1038/377355a0
51 NISHIMURAM, ISAKAF, ISHIBASHIM, et al.Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of drosophila hairy and enhancer of split[J]. Genomics, 1998, 49(1): 69-75. DOI: 10.1006/geno.1998.5213
52 OHTSUKAT, ISHIBASHIM, GRADWOHLG, et al. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation[J]. The EMBO Journal, 1999, 18(8): 2196-2207. DOI: 10.1093/emboj/18.8.2196
53 HAYASHIT, KOKUBOH, HARTMANB H, et al.Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea[J]. Developmental Biology, 2008, 316(1): 87-99. DOI: 10.1016/j.ydbio.2008.01.006
54 LIS D, MARKS, RADDE-GALLWITZK, et al.Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development[J]. BMC Dev Biol, 2008,8:20. DOI:10.1186/1471-213X-8-20
55 SHIF, CHENGY F, WANGX L, et al.Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhance[J]. Journal of Biological Chemistry, 2010, 285(1): 392-400. DOI: 10.1074/jbc.M109.059055
56 AGATHOCLEOUSM, IORDANOVAI, WILLARDSENM I, et al.A directional Wnt/beta-catenin-Sox2-proneural path-way regulates the transition from proliferation to differentiation in the Xenopus retina[J]. Development, 2009, 136(19): 3289-3299. DOI: 10.1242/dev.040451
57 JAYASENAC S, OHYAMAT, SEGILN, et al.Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode[J]. Development, 2008, 135(13): 2251-2261. DOI: 10.1242/dev.017905
58 JACQUESB E, PULIGILLAC, WEICHERTR M, et al.A dual function for canonical wnt/ β-catenin signaling in the developing mammal- ian cochlea[J]. Development, 2013, 140(1): 247-247. DOI: 10.1242/dev.080358
59 SHIF, HUL, JACQUESB E, et al.β-catenin is required for hair-cell differentiation in the cochlea [J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2014, 34(19): 6470-6479. DOI: 10.1523/JNEUROSCI.4305-13.2014
60 KUO B R, BALDWINE M, LAYMANW S, et al.In vivo cochlear hair cell generation and survival by coactivation of β-catenin and Atoh1[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2015, 35(30): 10786-10798. DOI: 10.1523/JNEUROSCI.0967-15.2015
61 NAKAMURAT, NAKAMURAT, MATSUMOTOK.The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology [J]. Journal of Cellular and Molecular Medicine, 2008,12(2): 391-408. DOI: 10.1111/j.1582-4934.2007.00201.x
62 MULVANEYJ F, THOMPKINSC, NODAT, et al.Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line[J]. Scientific Reports, 2016, 6:31668. DOI: 10.1038/srep31668
63 CHAIR, KUO B, WANGT, et al.Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea [J]. Proceedings of the National Academy of Scieces of the USA, 2012, 109(21):8167-8172. DOI: 10.1073/pnas.1202774109
64 ESTRACHS, AMBLERC A, CELSOC L L, et al.Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis[J]. Development, 2006, 133(22):4427-4438. DOI: 10.1242/dev.02644
65 PANNEQUINJ, BONNANSC, DELAUNAYN, et al.The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells[J]. Cancer Res, 2009,69(15): 6065-6073. DOI: 10.1158/0008-5472.CAN-08-2409
66 KATOHM, KATOHM.Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells[J]. Internationai Journal of Molecular Medicine, 2006, 17: 681-685. DOI: 10.3892/ijmm.17.4.681
67 COLLUG M, HIDALGO-SASTREA, ACARA, et al.Dishevelled limits Notch signalling through inhibition of CSL[J]. Development, 2012, 139(23): 4405-4415. DOI: 10.1242/dev.081885
68 DAVIESA, FORMSTONEC, MASONI, et al.Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-flamingo -1 protein [J]. Developmental Dynamics, 2005, 233(3): 998-1005. DOI: 10.1002/dvdy.20376
69 JAHANI, PANN, FRITZSCHB.Opportunities and limits of the one gene approach: The ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context[J]. Frontiers in Cellular Neuroscience, 2015,9: 26. DOI: 10.3389/fncel.2015.00026
70 KIERNANA E, PELLINGA L, LEUNGK K, et al.Sox2 is required for sensory organ development in the mammalian inner ear[J]. Nature, 2005,434(7036): 1031- 1035. DOI: 10.1038/nature03487
71 BOUCHARDM, CAPRONAD D, BUSSLINGERM, et al.Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation [J]. Bmc Developmental Biology, 2010, 10(1):89. DOI: 10.1186/1471-213X-10-89
72 ZOUD, SILVIUSD, FRITZSCHB, et al. Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes[J]. Development, 2004,131 (22): 5561-5572. DOI: 10.1242/dev.01437
73 NEVESJ, VACHKOVI, GIRALDEZF.Sox2 regulation of hair cell development: Incoherence makes sense[J]. Hearing Research, 2013, 297(2): 20-29. DOI: 10.1016/j.heares.2012.11.003
74 NEVESJ, PARADAC, CHAMIZOM, et al.Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: A mechanism for sensory organ specification[J]. Development, 2011,138(4):735-744. DOI: 10.1242/dev.060657
75 KEMPFLEJ S, TURBANJ L, EDGEA S B.Sox2 in the differentiation of cochlear progenitor cells[J]. Scientific Reports, 2016, 6: 23293. DOI:10.1038/srep23293
76 NEVESJ, KAMAIDA, ALSINAB, et al.Differential expression of Sox2 and Sox3 in neuronal and sensory progenitors of the developing inner ear of the chick[J]. Journal of Comparative Neurology, 2007,503(4):487-500. DOI: 10.1002/cne.21299
77 OESTERLEE C, CAMPBELLS, TAYLORR R, et al. Sox2 and Jagged1 expression in normal and drug-damaged adult mouse inner ear[J]. Journal of the Association for Research in Otolaryngology, 2008, 9(1): 65-89. DOI:10.1007/s10162-007-0106-7
78 WALLISD, HAMBLENM, ZHOUY.The zinc finger transcription factor Gfi1, implicated in lymphoma-genesis, is required for inner ear hair cell differentiation and survival[J]. Development, 2003,130(1): 221-232. DOI: 10.1242/dev.00190
79 KIRJAVAINENA, SULGM, HEYDF, et al.Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia[J]. Developmental Biology, 2008, 322(1): 33-45. DOI: 10.1016/j.ydbio.2008.07.004
80 SCHEFFERD I,SHENJ, COREYD P, alet, Gene expression by mouse inner ear hair cells during development[J].Journal of Neurosci, 2015, 35(16): 6366-6380. DOI: 10.1523/JNEUROSCI.5126-14.2015
81 COSTAA, POWELLL M, LOWELLS, et al.Atoh1 in sensory hair cell development: Constraints and cofactors[J]. Seminars in Cell and Developmental Biology, 2017, 65: 60-68. DOI: 10.1016/j.semcdb.2016.10.003
82 HERTZANOR, MONTCOUQUIOLM, RASHI-ELKELESS, et al.Transcription profiling of inner ears from Pou4f3 (ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene[J]. Human Molecular Genetics, 2004, 13(18): 2143-2153. DOI: 10.1093/hmg/ddh218
83 XIANGM, GAOW Q, HASSONT, et al.Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells[J]. Development, 1998,125(20): 3935-3946.
84 XIANGM, ZHOUL, MACKEJ P, et al.The Brn-3 family of POU-domain factors: Primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons[J]. Journal of Neuroscience, 1995,15:4762-4785. DOI: 10.1523/JNEUROSCI.15-07-04762.1995
85 XIANGM Q, GANL, LID Q,et al. Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development[J]. Proceedings of the National Academy of Sciences of the USA, 1997, 94(17): 9445-9450. DOI: 10.1073/pnas.94.17.9445
86 MASUDAM, DULOND, PAK K, et al.Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice[J]. Neuroscience, 2011, 197: 48-64. DOI: 10.1016/j.neuroscience.2011.09.033
87 LIUZ, FANGJ, DEARMANJ, et al.In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression[J]. Plos One, 2014, 9(2):e89377. DOI: 10.1371/journal.pone.0089377
88 MASUDAM, LIY, PAK K, et al.The promoter and multiple enhancers of the pou4f3 gene Regulate expression in inner ear hair cells[J]. Molecular Neurobiology, 2017,54(7):5414-5426. DOI: 10.1007/s12035-016-0060-7
89 LIUM, PEREIRAF A, PRICES D, et al. Essential role of BETA2/NeuroD1 in development of the vesti- bular and auditory systems[J]. Genes Dev, 2000, 14(22): 2839-2854. DOI: 10.1101/gad.840500
90 LEE J K, CHO J H, HWANGW S, et al.Expression of NeuroD/BETA2 in mitotic and postmitotic neuronal cells during the development of nervous system [J]. Developmental Dynamics, 2000, 217(4): 361-367. DOI: 10.1002/(SICI)1097-0177(200004)217:4<361::AID-DVDY3>3.0.CO;2-8
91 NAYAF J, HUANGH P, QIUY H, et al.Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuro D-deficient Mice[J]. Genes and Development, 1997, 11(18): 2323-2334. DOI: 10.1101/gad.11.18.2323
92 JAHANI, PANN, KERSIGOJ, et al.Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea[J]. Plos One, 2010,5(7): e11661. DOI: 10.1371/journal.pone.0011661
93 RAFTS, KOUNDAKJIANE J, QUINONESH, et al.Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development[J]. Development, 2007,134 (24): 4405-4415. DOI: 10.1242/dev.009118
94 BANNISTERA J, ZEGERMANP, PARTRIDGEJ F, et al.Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain[J]. Nature, 2001, 410(6824): 120-124. DOI: 10.1038/35065138
95 BERNSTEINB E, MIKKELSENT S, XIEX H, et al.A bivalent chromatin structure marks key developmental genes in embryonic stem cells[J]. Cell, 2006, 125(2): 315-326. DOI: 10.1016/j.cell.2006.02.041
96 KARMODIYAK, KREBSA R, OULAD-ABDELGHANIM, et al.H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells[J]. Bmc Genomics, 2012, 13: 424. DOI: 10.1186/1471-2164-13-424
97 RUDNICKIA, AVRAHAMK B.MicroRNAs: The art of silencing in the ear[J]. Embo Molecular Medicine, 2012,4(9): 849-859. DOI: 10.1002/emmm.201100922
98 MENCíAA, MODAMIO-H?YBJ?RS, REDSHAWN, et al. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss[J]. Nature Genetics, 2009, 41(5): 609-613. DOI: 10.1038/ng.355
99 EBEIDM, SRIPALP, PECKAJ, et al.Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells[J]. Plos One, 2017,12 (7):e0180855. DOI: 10.1371/journal.pone.0180855
100 STONEJ S, COTANCHED A.Identification of the timing of S phase and the patterns of cell proliferation during hair cell regeneration in the chick cochlea[J]. Journal of Comparative Neurology, 1994, 341(1): 50-67. DOI: 10.1002/cne.903410106
101 CAFAROJ, LEE G S, STONEJ S. Atoh1 expre- ssion defines activated progenitors and differentiating hair cells during avian hair cell regeneration [J]. Developmental Dynamics,2007,236(1):156-170. DOI: 10.1002/dvdy.21023
102 LUSHM E, PIOTROWSKIT.Sensory hair cell regeneration in the zebrafish lateral line[J]. Developmental Dynamics, 2014,243(10): 1187-11202. DOI: 10.1002/dvdy.24167
103 JACQUESB E, MONTGOMERYW H, URIBEPM, et al.The role of Wnt/beta-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line[J]. Developmental Neurobiology, 2014,74(4):438-456. DOI: 10.1002/dneu.22134
104 JIANGL, ROMERO-CARVAJALA, HAUGJ S,et al.Gene-expression analysis of hair cell regeneration in the zebrafish lateral line[J]. Proceedings of the National Academay of Sciences of the USA, 2014,111(14): 1383–1392. DOI: 10.1073/pnas.1402898111
105 DAUDETN, GIBSONR, SHANGJ, et al.Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds[J]. Developmental Biology, 2009, 326(1): 86-100. DOI: 10.1016/j.ydbio.2008.10.033
106 MA E Y, RUBELE W, RAIBLED W.Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line[J]. Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2008, 28(9): 2261-2273. DOI: 10.1523/JNEUROSCI.4372-07.2008
107 OUJIY, ISHIZAKAS, NAKAMURA-UCHIYAMAF, alet, Induction of inner ear hair cell-like cells from Math1-transfected mouse ES cells[J]. Cell Death and Disease,2013, 4(7): e700. DOI: 10.1038/cddis.2013.230
108 RONAGHIM, NASRM, EALYM, et al.Inner ear hair cell-like cells from human embryonic stem cells[J]. Stem Cells and and Development, 2014, 23(11): 1275-1284. DOI: 10.1089/scd.2014.0033
109 RICHARDSONR T, ATKINSONP J.Atoh1 gene therapy in the cochlea for hair cell regeneration[J]. Expert Opin Biol Ther, 2015.15(3): 417-430. DOI: 10.1517/14712598.2015.1009889
110 WALTERSB J, COAKE, DEARMANJ, et al.In vivo interplay between p27Kip1, GATA3, ATOH1, and POU4F3 converts non-sensory cells to hair cells in adult mice [J]. Cell Reports, 2017, 19(2): 307-320. DOI:10.1016/j.celrep.2017.03.044
111 BURNSJ C, COX B C, THIEDEB R, et al.In vivo proliferative regeneration of balance hair cells in newborn mice[J]. Journal of Neuroscience, 2012, 32(19): 6570-6577. DOI: 10.1523/JNEUROSCI.6274-11.2012
112 JUNGJ Y, AVENARIUSM R, ADAMSKYS, et al.SiRNA targeting Hes5 augments hair cell regeneration in aminoglycoside-damaged mouse utricle[J]. Molecular Therapy, 2013, 21(4): 834-841. DOI: 10.1038/mt.2013.18
113 LINV, GOLUBJ S, NGUYENT B, et al.Inhibition of notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2011, 31(43): 15329-15339. DOI: 10.1523/JNEUROSCI.2057-11.2011
114 YAMAMOTON, TANIGAKIK, TSUJIM, et al.Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas[J]. Journal of Molecular Medicine, 2006, 84(1): 37-45. DOI: 10.1007/s00109-005-0706-9
115 LIW Y , WUJ F, YANGJ M, et al.Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway[J]. PNAS, 2015,112(1): 166-171. DOI: 10.1073/pnas.1415901112
116 SHIF X, HUL X, EDGEA S.Generation of hair cells in neonatal mice by beta-catenin overexpression in Lgr5-positive cochlear progenitors[J]. Proceedings of the National Academy of Science of the USA, 2013, 110(34):13851-13856. DOI: 10.1073/pnas.1219952110
117 SHIF, KEMPFLEJ S, EDGEA S.Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2012,32(28): 9639- 9648. DOI: 10.1523/JNEUROSCI.1064-12.2012
118 CHAIR, XIAA, WANGT, et al.Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea [J]. Journal of the Association for Research in Otolaryngology, 2011,12(4): 455-469. DOI: 10.1007/s10162-011-0267-2
119 COSTAA, SANCHEZ-GUARDADOL, JUNIATS, et al.Generation of sensory hair cells by genetic programming with a combination of transcription factors [J]. Development, 2015, 142(11): 1948-1959. DOI: 10.1242/dev.119149
120 IKEDAR, PAK K, CHAVEZE, et al.Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells[J]. Molecular Neurobiology, 2015, 51(2): 672-684. DOI: 10.1007/s12035-014-8801-y
121 MASUDAM, PAK K, CHAVEZE, et al.TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1[J]. Developmental Biology, 2012, 372(1): 68-80. DOI: 10.1016/j.ydbio.2012.09.002
[1] 余晶晶, 金毅, 郑诗璐, 胡广, 刘金亮, 袁金凤, 刘佳佳, 于明坚. 千岛湖被子植物枝叶性状分化及其与种多度的关系[J]. 浙江大学学报(理学版), 2017, 44(4): 437-445.
[2] 程 琼 习玲玲 施清照. 再生丝素固定葡萄糖脱氢酶的生物传感器 [J]. 浙江大学学报(理学版), 1998, 25(4): 63-65.