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浙江大学学报(理学版)  2021, Vol. 48 Issue (5): 573-578    DOI: 10.3785/j.issn.1008-9497.2021.05.008
化学     
微型模块化微流控PET显像剂合成仪的研制及应用
裘佳萍1, 杜培臻2, 雷鸣1, 田梅2, 方群1, 张宏2,3, 徐光明1, 潘建章1
1.浙江大学 化学系,浙江 杭州 310058
2.浙江大学医学院附属第二医院,浙江 杭州 310009
3.浙江大学 生物医学工程与仪器科学学院,浙江 杭州 310058
Development of miniaturized modular microfluidic PET imaging agent synthesizer and its application
QIU Jiaping1, DU Peizhen2, LEI Ming1, TIAN Mei2, FANG Qun1, ZHANG Hong2,3, XU Guangming1, PAN Jianzhang1
1.Chemistry College, Zhejiang University, Hangzhou 310058, China
2.The Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China
3.College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310058, China
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摘要: 通过集成微流控流体操控、反应控制和电子控制3个系统,成功研制了模块化微流控芯片正电子发射计算机断层扫描(positron emission tomography,PET)显像剂合成仪。将不同结构的微流控芯片进行组合,实现富集、控温合成、分离、纯化等功能的模块化,以满足不同PET显像剂的合成制备要求。实验结果表明,用该仪器自动化合成18F-FDG显像剂仅需25 min,放射化学产率为48%~56%(未衰减校正,n>20),放射化学纯度高于98%,单次合成剂量为10~50 mCi,达到临床使用要求。
关键词: PET显像剂合成仪模块化自动化合成微流控芯片18F-FDG    
Abstract: A PET imaging agent synthesizer based on modular microfluidic chips is successfully developed. It integrates a microfluidic fluid handling system, a reaction control system and an electronic control system. Different microfluidic chips are designed to realize the modularization of enrichment, synthesis, separation, purification and other synthesis-related functions. By combining these chips, the synthesis of various PET imaging agents with different synthesis process could be achieved flexibly. A series of factors including microfluidic flow path, control circuit and key liquid handling components are considered comprehensively. Finally, the synthesizer is integrated and miniaturized. The automatic synthesis of 18F-FDG with this synthesizer took only 25 minutes, the radiochemical yield was 48%-56%(n>20), and the radiochemical purity was higher than 98%. The single synthetic dose was about 10-50 mCi, which meets the needs of clinical dose.
Key words: automated synthesis    modular    PET imaging agent synthesizer    microfluidic chip    18F-FDG
收稿日期: 2020-07-17 出版日期: 2021-09-15
CLC:  O 652.2  
基金资助: 国家自然科学基金资助项目(81327004).
通讯作者: ORCID: https://orcid.org/0000-0001-8164-7161,E-mail: hzhang21@zju.edu.cn     E-mail: hzhang21@zju.edu.cn
作者简介: 裘佳萍(1995—),ORCID: https://orcid.org/0000-0002-1466-3900,女,硕士研究生,主要从事PET显像剂合成仪研;
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引用本文:

裘佳萍, 杜培臻, 雷鸣, 田梅, 方群, 张宏, 徐光明, 潘建章. 微型模块化微流控PET显像剂合成仪的研制及应用[J]. 浙江大学学报(理学版), 2021, 48(5): 573-578.

QIU Jiaping, DU Peizhen, LEI Ming, TIAN Mei, FANG Qun, ZHANG Hong, XU Guangming, PAN Jianzhang. Development of miniaturized modular microfluidic PET imaging agent synthesizer and its application. Journal of Zhejiang University (Science Edition), 2021, 48(5): 573-578.

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https://www.zjujournals.com/sci/CN/10.3785/j.issn.1008-9497.2021.05.008        https://www.zjujournals.com/sci/CN/Y2021/V48/I5/573

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