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THE ANTIOXIDATIVE EFFECT OF SOYBEAN ISOFLAVONES
Zheng Gaoli, Zhu Shoumin, Liu Ziyi
Journal of ZheJiang University(Medical Science), 1997, 26(5): 196-199.
https://doi.org/10.3785/j.issn.1008-9292.1997.05.002
The antioxidative activity of soybean isoflavone extract was observed in high peroxidative mouse model induced by adriamycin(ADR). Mice was administered with 5 mg/kg ADR ip once every four days four times in two weeks. Soybean isoflavone extract was administered orally each day for 14 d. Soy beau isoflavone extract at dose of 200 mg/kg increased SOD activities in mouse erythrocytes, liver and heart by 97.0%, 42.0% and 97.0% respectively. At the dose of 50 mg/kg soybean isoflavone increased SOD activities in erythrocyte, liver and heart by 88.0%,33.0%and 46.0% respectively. The GSH-px activities in heart were increased by 122.3% and 99.4% in the two treated groups. GSH levels in liver were increased by 69.0% and 44.0% respectively. LPO levels in plasma, liver and heart were lowered by 26.5%,20.1%and 17.9% in group 3 and by 13.0%, 4.4% and 16.0% in group 4. The results suggested that soybean isoflavone extract demonstrated antioxidative activities.
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ASSESSMENT OF CARDIAC DAMAGE IN PATIENTS WITH DILATED CARDIOMYOPATHY BY ECHOCARDIOGRAPHY
Zheng Zhelan, Yao Lei, Xu Qibin
Journal of ZheJiang University(Medical Science), 1997, 26(5): 212-215.
https://doi.org/10.3785/j.issn.1008-9292.1997.05.007
The assessment of cardiac damage by echocardiography was made in 20 patients with dilated cardiomyopathy confirmed by clinical study. Compared with normal subjects,patients with dilated cardiomyopathy had severe abnormality in cardiac strugture, function, wall stress and LVEDP.The statistical analysis revealed positive correlation between EDV and LVMW, r=0.84(P<0.001) and negative correlation between SWI and SVR,r=-0.73(P<0.01);EDσ and RWT,r=-0.70(P<0.001); ESσ and FS, r=-0.46(P<0.05). It demonstrated:1. Dilated cardiomyopathy had a higher preload(EDV) with afterload(ESσ) mismatched,which could play an important role in accelerating the disease. 2. Relative wall thickness decrease could lead to increase of left ventricular wall stress which indicated that hypertrophy of the heart muscle did not compensate enough. 3. LVEDP of DCM was higher.
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CHARACTERISTICS OF RESISTANCE TO SEVENTEEN ANTIMICROBIAL AGENTS AMONG NONFERMENTER ISOLATES
Zhu Shanming, Zhang Rong, Xuan Guida
Journal of ZheJiang University(Medical Science), 1997, 26(5): 219-222.
https://doi.org/10.3785/j.issn.1008-9292.1997.05.009
A total of 1362 nonfermenter strains was isolated from pathological samples(such as sputum, urine, wounds, blood and others) and collected during a period from June 1994 to June 1996. Isolates were identified as nonfermenters based upon Disk diffusion and Vitek-Ams system test. The resistance rates of ceftazidime, ciprofloxacin, norftoxacin, imipenem, cefoperazone/sulbactam and polymyxin B against strains of nonfermenters were accepted. The resistance rates of others were high(over 40%). The results are helpful in selecting antibiotics for clinical use.
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9 articles
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