Clinical features and prognosis of cervical adenocarcinoma and adenosquamous carcinoma: an analysis of 237 cases

doi:10.3785/j.issn.1008-9292.2018.08.05

J Zhejiang Univ (Med Sci)

2018, Vol. 47

Issue (4): 357-361 DOI: 10.3785/j.issn.1008-9292.2018.08.05

Clinical features and prognosis of cervical adenocarcinoma and adenosquamous carcinoma: an analysis of 237 cases

CHEN Qian(

),LIU Lu,ZHANG Jingjing,HAN Sai,CUI Baoxia,ZHANG Youzhong*(

),KONG Beihua

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China

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Abstract

Objective: To analyze the clinical features and prognosis of cervical adenocarcinoma (AC) and adenosquamous carcinoma of cervix (ASC). Methods: The clinical data of 237 patients, including 201 cases of AC and 36 cases of ASC (FIGO stage ⅠB1-ⅡA), who underwent surgery in Qilu Hospital between September 2007 and September 2016 were reviewed. Clinical features of two groups were compared, and Kaplan-Meier survival analysis was performed to evaluate the prognosis. Results: A larger proportion of ASC patients had lymphovascular space invasion compared with AC patients (P < 0.01), but no significant differences were observed in the age, FIGO stage, size of tumor, depth of stromal invasion, parametrial invasion, lymphatic metastasis and risk grade between two groups (all P>0.05). The 5-year overall survival rates of AC and ASC groups were 79.4% and 78.3%, and the 5-year recurrence-free survival rates were 77.4% and 73.0%. Among patients received concurrent chemoradiotherapy, the 5-year overall survival rates were 71.0% and 61.4%, and the 5-year recurrence-free survival rates were 68.8% abd 61.1%, respectively. No significant differences were observed in 5-year overall survival rates and recurrence-free survival rates between AC and ASC patients (all P>0.05). Conclusion: Lymphovascular space invasion was more likely to occur in patients with ASC, but there was no significant difference in the prognosis between AC and ASC patients.

Key words： Uterine cervical neoplasms/pathology Carcinoma, squamous cell/pathology Adenocarcinoma/pathology Neoplasm invasiveness Lymphatic metastasis Survival rate Prognosis

Received: 03 July 2018 Published: 04 December 2018

CLC:

R737.33

Corresponding Authors: ZHANG Youzhong E-mail: 18769781275@163.com;zhangyouzhong@sdu.edu.cn

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	CHEN Qian
	LIU Lu
	ZHANG Jingjing
	HAN Sai
	CUI Baoxia
	ZHANG Youzhong
	KONG Beihua

Cite this article:

CHEN Qian,LIU Lu,ZHANG Jingjing,HAN Sai,CUI Baoxia,ZHANG Youzhong,KONG Beihua. Clinical features and prognosis of cervical adenocarcinoma and adenosquamous carcinoma: an analysis of 237 cases. J Zhejiang Univ (Med Sci), 2018, 47(4): 357-361.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2018.08.05 OR http://www.zjujournals.com/med/Y2018/V47/I4/357

237例宫颈腺癌及腺鳞癌患者临床特征及预后分析

目的: 探讨宫颈腺癌和宫颈腺鳞癌患者的临床特征和预后差异。方法: 回顾性分析2007年9月至2016年9月因ⅠB1~ⅡA期宫颈腺癌（201例）或宫颈腺鳞癌（36例）在山东大学齐鲁医院手术治疗患者的临床资料。比较两组的临床特征，并采用Kaplan-Meier生存曲线对两种组织学类型宫颈癌的预后进行评价。结果: 宫颈腺鳞癌组淋巴血管浸润比例较宫颈腺癌组高（P < 0.01），而在年龄、FIGO分期、肿瘤直径、间质浸润深度、宫旁浸润、淋巴结转移和危险分级方面两组差异均无统计学意义（均P>0.05）。宫颈腺癌组和宫颈腺鳞癌组患者5年总存活率分别为79.4%和78.3%，5年无复发存活率分别为77.4%和73.0%，组间差异均无统计学意义（均P>0.05）。术后接受同步放射治疗和化疗的患者中，5年总存活率分别为71.0%和61.4%，5年无复发存活率分别为68.8%和61.1%，组间差异均无统计学意义（均P>0.05）。结论: 宫颈腺鳞癌较宫颈腺癌更易发生淋巴血管浸润，但两者的预后相似。

关键词： 宫颈肿瘤/病理学, 癌, 鳞状细胞/病理学, 腺癌/病理学, 肿瘤浸润, 淋巴转移, 存活率, 预后

Tab 1 Clinical features of the adenocarcinoma and adenosquamous carcinoma groups

Fig 1 Kaplan-Meier survival curves for cervical adenocarcinoma and adenosquamous carcinoma patients

Fig 2 Kaplan-Meier survival curves for cervical adenocarcinoma and adenosquamous carcinoma patients received adjuvant CCRT


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