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浙江大学学报（医学版）
J Zhejiang Univ (Med Sci)  2018, Vol. 47 Issue (1): 75-81    DOI: 10.3785/j.issn.1008-9292.2018.02.11
    
Regulatory effect of Vav1 on T cells and its relation to clinical diseases
ZHANG Yuchuan(),CHEN Wei*()
Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China
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Abstract  

Vav1, as a key downstream signaling molecule of T cell receptor, includes a catalytic core DH-PH-ZF domain with the function as guanine nucleotide exchange factor (GEF), and a SH3-SH2-SH3 domain with the function as adaptor protein. These two structures of Vav1 play different roles in the development, activation, proliferation and function of T cells, and thereby exert the different regulatory effect on the occurrence and development of autoimmune disease, graft rejection, cancer and other clinical conditions, implicating that Vav1 might be a potential therapeutic target for these diseases. This paper reviews the role of Vav1 in T cells and the occurrence of related diseases.

Key words： T-lymphocytes/physiology      Guanine nucleotide exchange factors/physiology      Autoimmune diseases      Graft rejection      Lymphoma, T-cell      Review     
Received: 20 November 2017      Published: 12 June 2018
CLC:  R392  
Corresponding Authors: CHEN Wei     E-mail: alstraybird@163.com;chenwei566@zju.edu.cn
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Cite this article:

ZHANG Yuchuan,CHEN Wei. Regulatory effect of Vav1 on T cells and its relation to clinical diseases. J Zhejiang Univ (Med Sci), 2018, 47(1): 75-81.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2018.02.11     OR     http://www.zjujournals.com/med/Y2018/V47/I1/75


Vav1对T细胞的调控作用及其与相关疾病的关系

Vav1作为T细胞受体下游的关键信号分子，拥有鸟苷酸交换因子功能的催化核心结构DH-PH-ZF和接头蛋白功能的SH3-SH2-SH3结构，因而在T细胞发育、活化、增殖和功能发挥等各个阶段，以及在自身免疫性疾病、移植排斥和肿瘤等发生、发展中具有不同的调控作用，可为临床治疗提供潜在靶点。本文综述了Vav1对T细胞的调控作用及其与相关疾病的关系。


关键词： T淋巴细胞/生理学,  鸟嘌呤核苷酸交换因子类/生理学,  自身免疫疾病,  移植物排斥,  淋巴瘤, T细胞,  综述 
Fig 1 Schematic diagram of Vav1
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